New Pyrrolo[2,1-a]phthalazine Derivatives by One-Pot Three-Component Synthesis

被引：32
|
作者：
Dumitrascu, Florea [1 ]
Caproiu, Miron Teodor [1 ]
Georgescu, Florentina [2 ]
Draghici, Bogdan [1 ]
Popa, Marcel Mirel [1 ]
Georgescu, Emilian [2 ]
机构：
[1] Acad Romana, Ctr Organ Chem CD Nenitzescu, Bucharest 060023, Romania
[2] Oltchim Res Ctr, Ramnicu Valcea 240050, Romania
来源：
SYNLETT | 2010年 / 16期
关键词：
1,3-dipolar cycloaddition; N-ylide; pyrrolo[2,1-a]phthalazine; multicomponent reaction;
D O I：
10.1055/s-0030-1258035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of the pyrrolo[2,1-a]phthalazine derivatives was performed by an efficient one-pot three-component reaction starting from phthalazine, 2-bromoacetophenones and nonsymmetrical and symmetrical acetylenic dipolarophiles in 1,2-epoxybutane as both reaction medium and HBr scavenger. The structure of the compounds was assigned by IR and NMR spectroscopy.
引用
收藏
页码：2407 / 2410
页数：4
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