New Pyrrolo[2,1-a]phthalazine Derivatives by One-Pot Three-Component Synthesis

被引：32

作者：

Dumitrascu, Florea ^{[1
]}

Caproiu, Miron Teodor ^{[1
]}

Georgescu, Florentina ^{[2
]}

Draghici, Bogdan ^{[1
]}

Popa, Marcel Mirel ^{[1
]}

Georgescu, Emilian ^{[2
]}

机构：

[1] Acad Romana, Ctr Organ Chem CD Nenitzescu, Bucharest 060023, Romania

[2] Oltchim Res Ctr, Ramnicu Valcea 240050, Romania

来源：

SYNLETT | 2010年 / 16期

关键词：

1,3-dipolar cycloaddition; N-ylide; pyrrolo[2,1-a]phthalazine; multicomponent reaction;

D O I：

10.1055/s-0030-1258035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the pyrrolo[2,1-a]phthalazine derivatives was performed by an efficient one-pot three-component reaction starting from phthalazine, 2-bromoacetophenones and nonsymmetrical and symmetrical acetylenic dipolarophiles in 1,2-epoxybutane as both reaction medium and HBr scavenger. The structure of the compounds was assigned by IR and NMR spectroscopy.

引用

页码：2407 / 2410

页数：4

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