Photoinduced Kochi Decarboxylative Elimination for the Synthesis of Enamides and Enecarbamates from N-Acyl Amino Acids

被引：39

作者：

Cartwright, Kaitie C. ^{[1
]}

Lang, Simon B. ^{[1
]}

Tunge, Jon A. ^{[1
]}

机构：

[1] Univ Kansas, Dept Chem, 2010 Malott Hall,1251 Wescoe Hall Dr, Lawrence, KS 66045 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 05期

基金：

美国国家科学基金会;

关键词：

ELECTRON-TRANSFER OXIDATION; ALKYL RADICALS; ISOMERIZATION; HYDROAMINATION; ALKENES; REDUCTION; AMIDES; ALLYLAMIDES; RUTHENIUM; AMINATION;

D O I：

10.1021/acs.joc.9b00167

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Decarboxylative elimination of easily accessible N-acyl amino acids to provide enamide and enecarbamate building blocks has been realized through the combination of an organophotoredox catalyst and copper acetate as the terminal oxidant. This operationally simple process utilizes inexpensive and readily available reagents without preactivation of the carboxylic acid. Enamides and enecarbamates are now accessible directly from N-acyl amino acids consequently improving upon the utility of Kochi's oxidative decarboxylation of carboxylic acids.

引用

页码：2933 / 2940

页数：8

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