Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB

被引：25
|
作者：
Trevisan, Glauce L. [1 ]
Oliveira, Ernna H. D. [2 ]
Peres, Nalu T. A. [2 ]
Cruz, Aline H. S. [2 ]
Martinez-Rossi, Nilce M. [2 ]
Rossi, Antonio [1 ]
机构：
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, BR-14049900 Ribeirao Preto, SP, Brazil
来源：
FEBS LETTERS | 2011年 / 585卷 / 21期
基金：
巴西圣保罗研究基金会;
关键词：
pH Regulation; RNA splicing; Phosphate regulation; pacC; palB; Aspergillus nidulans; SHOCK-PROTEIN GENES; EXTRACELLULAR PH; EXPRESSION; MUTATION; IDENTIFICATION; PHOSPHATASES; PROTEOLYSIS; SECRETION;
D O I：
10.1016/j.febslet.2011.09.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fungi have evolved elaborate signal transduction networks for remodeling metabolic pathways to scavenge nutrients, including the secretion of nutritional enzymes. This adaptive response involves the conserved PacC/Pal signal transduction pathway, which mediates the transcriptional response to ambient pH. In this study, we show that transcription of the gene for PacC is modulated in response to nutrient changes, phosphate and carbon sources, and pH. In addition, we show that transcription of pacC is modulated in response to alternative RNA splicing of the palB gene. These results reveal novel aspects of the complex network involved in modulation of pacC. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：3442 / 3445
页数：4
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