A case of atypical hemolytic uremic syndrome in a second renal transplant

被引：1

作者：

Zwang, Nicholas A. ^{[1
,2
,5
]}

Ho, Bing ^{[1
]}

Kanwar, Yashpal S. ^{[3
]}

Lewis, Brad ^{[4
]}

Cusick, Matthew ^{[1
]}

Friedewald, John J. ^{[1
,2
,3
,4
,5
]}

Gallon, Lorenzo ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Comprehens Transplant Ctr, Chicago, IL 60611 USA

[2] Northwestern Univ, Mcgaw Med Ctr, Chicago, IL 60611 USA

[3] Northwestern Mem Hosp, Dept Pathol, Chicago, IL 60611 USA

[4] Machaon Diagnost, Oakland, CA USA

[5] Northwestern Mem Hosp, Arkes Family Pavil Suite 1900,676N St Clair, Chicago, IL 60611 USA

来源：

JOURNAL OF NEPHROLOGY | 2018年 / 31卷 / 01期

关键词：

Kidney transplantation; Graft failure; Atypical hemolytic uremic syndrome; Histocompatibility; Complement biology; CYCLOSPORINE-SIROLIMUS COMBINATION; THROMBOTIC MICROANGIOPATHY; KIDNEY-TRANSPLANTATION; FACTOR-I; COMPLEMENT; MUTATIONS; ECULIZUMAB; EXPRESSION; INHIBITOR; ANTIBODY;

D O I：

10.1007/s40620-016-0373-7

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Atypical hemolytic uremic syndrome (aHUS) has gained increased visibility over several years as an important cause of renal failure. Unfortunately, diagnosis is often difficult because individual courses can be highly variable depending the causative genetic mutations. Here we present the case of a patient with a failed renal allograft and acute failure of a second allograft who was ultimately diagnosed with aHUS. Interestingly, he developed early de novo donor specific antibodies (DSA) after the second renal transplant in context of likely recurrent aHUS. Terminal complement inhibition with eculizumab resulted in prompt improvement of renal allograft function.

引用

页码：165 / 172

页数：8

共 50 条

[21] ATYPICAL HEMOLYTIC UREMIC SYNDROME: AN ATYPICAL CAUSE OF RENAL FAILURE IN THE ICU
Augenstein, Cheryl
CHEST, 2022, 162 (04) : 792A - 792A
[22] Kidney Transplant Outcomes in Patients with Atypical Hemolytic Uremic Syndrome
Balwani, Manish R.
Pasari, Amit S.
Gurjar, Prasad
Bhawane, Amol
Bawankule, Charulata
Tolani, Priyanka
Kashiv, Pranjal
Dubey, Shubham
Katekhaye, Vijay M.
TRANSPLANTATION PROCEEDINGS, 2023, 55 (05) : 1312 - 1315
[23] ABO Incompatible Kidney Transplant in a Patient With Atypical Hemolytic Uremic Syndrome: Case Report
Balwani, Manish R.
Pasari, Amit S.
Bawankule, Charulata
Bhawane, Amol
Tolani, Priyanka
Katekhaye, Vijay M.
TRANSPLANTATION PROCEEDINGS, 2023, 55 (08) : 1913 - 1916
[24] Atypical hemolytic uremic syndrome
Kavanagh, David
Goodship, Timothy H. J.
CURRENT OPINION IN HEMATOLOGY, 2010, 17 (05) : 432 - 438
[25] Atypical hemolytic uremic syndrome
Loirat, Chantal
Fremeaux-Bacchi, Veronique
ORPHANET JOURNAL OF RARE DISEASES, 2011, 6
[26] Atypical Hemolytic Uremic Syndrome
Dixon, Bradley P.
Gruppo, Ralph A.
PEDIATRIC CLINICS OF NORTH AMERICA, 2018, 65 (03) : 509 - +
[27] Atypical hemolytic uremic syndrome
Chantal Loirat
Véronique Frémeaux-Bacchi
Orphanet Journal of Rare Diseases, 6
[28] Atypical hemolytic uremic syndrome
Blasco Pelicano, Miquel
Rodriguez de Cordoba, Santiago
Campistol Plana, Josep M.
MEDICINA CLINICA, 2015, 145 (10): : 438 - 445
[29] Atypical hemolytic uremic syndrome
Afshar-Kharghan, Vahid
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2016, : 217 - 225
[30] Renal Transplant lmmunosuppression in Patients With Hemolytic Uremic Syndrome: Four Case Reports
Galindo, P.
Ramirez, M.
Perez Marfil, A.
Espigares, M. J.
Osoria, J. M.
Leiva, R.
Ruiz Fuentes, M. C.
De Gracia, C.
Osuna, A.
TRANSPLANTATION PROCEEDINGS, 2018, 50 (02) : 572 - 574

← 1 2 3 4 5 →