A new 'Linc' between noncoding RNAs and blood development

被引：43
|
作者：
Paralkar, Vikram R. [2 ]
Weiss, Mitchell J. [1 ]
机构：
[1] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA
[2] Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA
来源：
GENES & DEVELOPMENT | 2011年 / 25卷 / 24期
关键词：
long noncoding RNA; erythroid terminal differentiation; apoptosis; GENE-EXPRESSION; CHROMATIN; DIFFERENTIATION; CELLS; COMPLEXES; REVEALS;
D O I：
10.1101/gad.183020.111
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.
引用
收藏
页码：2555 / 2558
页数：4
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