Renal Function and Blood Pressure: Molecular Insights into the Biology of Endothelin-1

被引:0
|
作者
Vignon-Zellweger, Nicolas [2 ]
Heiden, Susi [2 ]
Emoto, Noriaki [1 ,2 ]
机构
[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
[2] Kobe Pharmaceut Univ, Dept Clin Pharm, Kobe, Hyogo 658, Japan
来源
ENDOTHELIN IN RENAL PHYSIOLOGY AND DISEASE | 2011年 / 172卷
关键词
DUCT-SPECIFIC KNOCKOUT; MEDULLARY COLLECTING DUCT; RAT MESANGIAL CELLS; RECEPTOR-DEFICIENT RATS; HIGH-SALT DIET; NA+-K+-ATPASE; ETB-RECEPTOR; B-RECEPTOR; NITRIC-OXIDE; CAUSES HYPERTENSION;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The therapeutic implications of the actions of endothelin (ET)-1 upon renal and cardiovascular function are evident. Among other diseases, ET-1 is recognized to be involved in hypertension and renal failure and, in a rush to develop novel treatments, has been extensively studied. However, given the broad localization of the two receptors (ETA and ETB) and the diverse effects resulting from their activation, analysis of the role of ET-1 in kidney-regulated blood pressure remains complicated. Moreover, the actions of ET-1 depend upon the cell type and physiological situation. To add to the complexity, both receptors often activate opposing signaling pathways within a single cell. Thus, until recently, reliable insights into the respective involvement of both receptors in the physiology and pathology of the kidney were eagerly awaited. These have been obtained using mice that are genetically modified for different members of the ET system. In this article, the molecular biology of ET-1 and its receptors in the control of renal vasculature tonicity, glomerular function, and management of water and salt reabsorption is discussed. The role of renal ET-1 in the context of blood pressure regulation will be discussed, and the potential of utilizing ET receptor antagonism in the treatment and prevention of glomerular and proteinuric diseases is also outlined. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:18 / 34
页数:17
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