Small leucine-rich repeat proteoglycans in corneal inflammation and wound healing

被引：32
|
作者：
Frikeche, Jihane [1 ]
Maiti, George [1 ]
Chakravarti, Shukti [1 ,2 ,3 ]
机构：
[1] Johns Hopkins Sch Med, Dept Med, Baltimore, MD USA
[2] Johns Hopkins Sch Med, Dept Cell Biol, Baltimore, MD USA
[3] Johns Hopkins Sch Med, Dept Ophthalmol, Baltimore, MD USA
来源：
EXPERIMENTAL EYE RESEARCH | 2016年 / 151卷
关键词：
SLRP; Lumican; Keratocan; Biglycan; Decorin; Osteoglycin; Fibromodulin; Cornea wound healing; TLR; KERATAN SULFATE PROTEOGLYCAN; TOLL-LIKE RECEPTORS; GROWTH-FACTOR-BETA; HUMAN FIBROMODULIN GENE; EXTRACELLULAR-MATRIX; COLLAGEN FIBRILLOGENESIS; INNATE IMMUNITY; CORE PROTEIN; HIGH MYOPIA; TGF-BETA;
D O I：
10.1016/j.exer.2016.08.015
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The small leucine rich repeat proteoglycans are major components of the cornea. Lumican, keratocan, decorin, biglycan and osteoglycin are present throughout the adult corneal stroma, and fibromodulin in the peripheral limbal area. In the cornea literature these proteoglycan have been reviewed as structural, collagen fibril-regulating proteins of the cornea. However, these proteoglycans are members of the leucine-rich-repeat superfamily, and share structural similarities with pathogen recognition toll-like receptors. Emerging studies are showing that these have a range of interactions with cell surface receptors, chemokines, growth factors and pathogen associated molecular patterns and are able to regulate host immune response, inflammation and wound healing. This review discusses what is known about their innate immune-related role directly in the cornea, and studies outside the field that find interesting links with innate immune and wound healing responses that are likely to be relevant to the ocular surface. In addition, the review discusses phenotypes of mice with targeted deletion of proteoglycan genes and genetic variants associated with human pathologies. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：142 / 149
页数：8
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