A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan

被引：21

作者：

Owada, Yohei ^{[1
]}

Oshiro, Yukio ^{[1
]}

Inagaki, Yuki ^{[1
]}

Harada, Hiroshi ^{[2
]}

Fujiyama, Nobuhiro ^{[3
]}

Kawagishi, Naoki ^{[4
]}

Yagisawa, Takashi ^{[5
]}

Usui, Joichi ^{[6
]}

Akutsu, Naotake ^{[7
]}

Itabashi, Yoshihiro ^{[8
]}

Saito, Kazuhide ^{[9
]}

Watarai, Yoshihiko ^{[10
]}

Ichimaru, Naotsugu ^{[11
]}

Imamura, Ryoichi ^{[12
]}

Kyakuno, Miyaji ^{[13
]}

Ide, Kentaro ^{[14
]}

Shibuya, Yuichi ^{[15
]}

Okabe, Yasuhiro ^{[16
]}

Ono, Minoru ^{[17
]}

Sasaki, Konosuke ^{[18
]}

Shiose, Akira ^{[19
]}

Yamagishi, Kazumasa ^{[20
]}

Ohnishi, Hiroshi ^{[21
]}

Nagashima, Shigeo ^{[21
]}

Takahashi, Masaharu ^{[21
]}

Yuzawa, Kenji ^{[22
]}

Okamoto, Hiroaki ^{[21
]}

Ohkohchi, Nobuhiro ^{[1
]}

机构：

[1] Univ Tsukuba, Fac Med, Dept Gastrointestinal & Hepatobiliary Pancreat Su, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[2] Sapporo City Gen Hosp, Kidney Transplant Surg, Chuou Ku, Sapporo, Hokkaido, Japan

[3] Akita Univ Hosp, Ctr Kidney Dis & Transplantat, Akita, Japan

[4] JCHO Sendai Hosp, Dept Surg, Aoba Ku, Sendai, Miyagi, Japan

[5] Jichi Med Univ Hosp, Dept Renal Surg & Transplantat, Shimotsuke, Tochigi, Japan

[6] Univ Tsukuba, Fac Med, Dept Nephrol, Tsukuba, Ibaraki, Japan

[7] Chiba East Natl Hosp, Dept Surg, Chiba, Chiba, Japan

[8] Toho Univ, Fac Med, Dept Nephrol, Ota Ku, Tokyo, Japan

[9] Niigata Univ, Grad Sch Med & Dent Sci, Dept Regenerat & Transplant Med, Div Urol,Chuo Ku, Niigata, Japan

[10] Nagoya Daini Red Cross Hosp, Dept Transplant Surg, Showa Ku, Nagoya, Aichi, Japan

[11] Osaka Univ, Dept Adv Technol Transplantat, Grad Sch Med, Suita, Osaka, Japan

[12] Osaka Univ, Dept Urol, Grad Sch Med, Suita, Osaka, Japan

[13] Takatsuki Gen Hosp, Dept Renal Transplantat, Takatsuki, Osaka, Japan

[14] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, Minami Ku, Hiroshima, Japan

[15] Kochi Hlth Sci Ctr, Dept Gastroenterol Surg, Kochi, Kochi, Japan

[16] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Higashi Ku, Fukuoka, Japan

[17] Univ Tokyo, Grad Sch Med, Dept Cardiac Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo, Japan

[18] Tohoku Univ, Div Cardiovasc Surg, Grad Sch Med, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi, Japan

[19] Kyushu Univ, Dept Cardiovasc Surg, Fac Med Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Japan

[20] Univ Tsukuba, Fac Med, Dept Publ Hlth Med, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan

[21] Jichi Med Univ, Dept Infect & Immun, Div Virol, Sch Med, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan

[22] Natl Hosp Org Mito Med Ctr, Dept Transplantat Surg, 280 Sakuranosato, Ibaraki, Ibaraki, Japan

来源：

TRANSPLANTATION | 2020年 / 104卷 / 02期

关键词：

LIVER; STRAINS; ANTIBODIES; FEATURES;

D O I：

10.1097/TP.0000000000002801

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Recently, chronic hepatitis E has been reported in solid organ transplant (SOT) recipients in European countries. Previously, we clarified the prevalence of hepatitis E virus (HEV) infection in Japanese liver transplant recipients and identified 2 chronic hepatitis E patients infected by blood transfusion. However, the rate of HEV infection in recipients of SOTs other than liver in Japan remains unclear, so we conducted a nationwide survey to clarify the prevalence of chronic HEV infection in Japanese heart and kidney transplant recipients. Methods. A total of 99 heart and 2526 kidney transplant recipients in 17 hospitals in Japan were examined for the presence of the IgG class of anti-HEV antibodies as well as for serum HEV RNA. Results. The prevalence of anti-HEV IgG among heart and kidney transplant recipients was 7.07% (7/99) and 4.08% (103/2526), respectively. One heart transplant patient (1.01%) and 11 kidney transplant patients (0.44%) were found to be positive for HEV RNA. The HEV isolates from all viremic patients were typed as genotype 3. Four patients developed chronic hepatitis E after transplantation. Three patients were treated with ribavirin; their liver enzymes normalized, and HEV RNA became negative immediately. Sustained virologic response was achieved in all cases. Conclusions. This is the first nationwide survey of HEV infection in Japanese heart and kidney transplant recipients. The prevalence of anti-HEV IgG and HEV RNA in heart and kidney transplant recipients in Japan was lower than that in European countries. Of note, 42% of viremic transplant patients developed chronic hepatitis.

引用

页码：437 / 444

页数：8

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