Pathobiological Implications of MUC16/CA125 Expression in Intrahepatic Cholangiocarcinoma-Mass Forming Type

被引：80
|
作者：
Higashi, Michiyo [1 ]
Yamada, Norishige [1 ]
Yokoyama, Seiya [1 ]
Kitamoto, Sho [1 ]
Tabata, Kazuhiro [1 ]
Koriyama, Chihaya [2 ]
Batra, Surinder K. [3 ,4 ]
Yonezawa, Suguru [1 ]
机构：
[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Human Pathol, Field Oncol, Kagoshima 8908544, Japan
[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Epidemiol & Prevent Med, Kagoshima 8908544, Japan
[3] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Biochem, Omaha, NE USA
[4] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Mol Biol, Omaha, NE USA
来源：
PATHOBIOLOGY | 2012年 / 79卷 / 02期
关键词：
Cholangiocarcinoma; MUC16; CA125; Prognosis; PROGNOSTIC-FACTOR; EXTRACELLULAR SUPERSTRUCTURE; SURGICAL-TREATMENT; CA-125; GENE; MUC4; MUCINS; CA125; NEOPLASMS; CARCINOMA; DIAGNOSIS;
D O I：
10.1159/000335164
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Objectives: MUC16 carries the peptide epitope CA125, which is well known as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been reported not only in patients with ovarian cancer but also in patients with liver diseases. We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-ME) tissues. Methods: We examined the expression of MUC16 by immunohistochemical analyses using the monoclonal antibody M11 in ICC-MF tissues from 63 patients. To compare the prevalence of each mucin expression by clinicopathological features, appropriate statistical analysis was performed. Results: MUC16 was detected in 48% of samples (30/63). After adjusting for the effects of other prognostic factors, multi-variate survival analysis revealed that MUC16 expression is a significant independent factor of poor prognosis (p = 0.005). Conclusion:The current results indicate that MUC16 expression is a prognostic factor of poor survival in ICC-MF. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：101 / 106
页数：6
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