Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration

被引：22
|
作者：
Groves, Alistair [1 ,2 ]
Sun, Jinwei [1 ,2 ,3 ]
Parke, Hal R. I. [1 ,2 ]
Callingham, Michael [1 ,2 ]
Argent, Stephen P. [2 ]
Taylor, Laurence J. [2 ]
Lam, Hon Wai [1 ,2 ]
机构：
[1] Univ Nottingham, GlaxoSmithKline Carbon Neutral Labs Sustainable C, Jubilee Campus,Triumph Rd, Nottingham NG7 2TU, England
[2] Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England
[3] Nanjing Univ Informat Sci & Technol, Jiangsu Collaborat Innovat Ctr Atmospher Environm, Jiangsu Key Lab Atmospher Environm Monitoring & P, Sch Chem & Mat Sci, Nanjing 210044, Jiangsu, Peoples R China
来源：
CHEMICAL SCIENCE | 2020年 / 11卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
REMOTE FUNCTIONALIZATION; C-C; ARYLBORONIC ACIDS; RHODIUM; ISOMERIZATION; ALLYLATION; 1,3-ENYNES; COMPLEXES; EFFICIENT; REAGENTS;
D O I：
10.1039/c9sc06309a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition-cyclization reactions is an alkenyl-to-aryl 1,4-Rh(i) migration, which enables arylboronic acids to function effectively as 1,2-dimetalloarene surrogates.
引用
收藏
页码：2759 / 2764
页数：6
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