Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

被引：1518

作者：

Wu, Aiping ^{[1
,2
,8
]}

Peng, Yousong ^{[3
]}

Huang, Baoying ^{[4
]}

Ding, Xiao ^{[1
,2
,8
]}

Wang, Xianyue ^{[1
,2
,8
]}

Niu, Peihua ^{[4
]}

Meng, Jing ^{[1
,2
,8
]}

Zhu, Zhaozhong ^{[3
]}

Zhang, Zheng ^{[3
]}

Wang, Jiangyuan ^{[1
,2
,8
]}

Sheng, Jie ^{[1
,2
,8
]}

Quan, Lijun ^{[5
]}

Xia, Zanxian ^{[6
,9
,10
]}

Tan, Wenjie ^{[4
]}

Cheng, Genhong ^{[7
]}

Jiang, Taijiao ^{[1
,2
,8
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Hunan Univ, Hunan Prov Key Lab Med Virol, Coll Biol, Changsha 410082, Peoples R China

[4] China CDC, Natl Inst Viral Dis Control & Prevent, Natl Hlth & Family Planning Commiss, Key Lab Med Virol, Beijing 102206, Peoples R China

[5] Soochow Univ, Sch Comp Sci & Technol, Suzhou, Peoples R China

[6] Cent South Univ, Sch Life Sci, Dept Cell Biol, Changsha 410013, Peoples R China

[7] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[8] Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China

[9] Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Hunan Key Lab Anim Models Human Dis, Changsha 410013, Peoples R China

[10] Cent South Univ, Sch Life Sci, Ctr Med Genet, Changsha 410013, Peoples R China

来源：

CELL HOST & MICROBE | 2020年 / 27卷 / 03期

基金：

中国国家自然科学基金;

关键词：

RECEPTOR;

D O I：

10.1016/j.chom.2020.02.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

引用

页码：325 / 328

页数：4

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