A facile preparation and crystal structure of romipeptide A

被引：0

作者：

Zhang, Hui ^{[1
,2
]}

Qi, Huan ^{[3
]}

Duan, Wen-kai ^{[2
]}

Zhang, Ji ^{[1
]}

Wang, Ji-dong ^{[3
]}

Xiang, Wen-sheng ^{[1
]}

机构：

[1] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150030, Peoples R China

[2] Taizhou Vocat Coll Sci & Technol, Taizhou 318000, Peoples R China

[3] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2022年 / 75卷 / 01期

关键词：

DEPSIPEPTIDE; FK228;

D O I：

10.1038/s41429-021-00487-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A double disulfide tethering depsipeptide dimer, romipeptide A (1) was prepared by NaOH catalyzed dimerization of romidepsin. Its structure was determined by analysis of NMR and HR-ESI-MS data as well as single crystal X-ray diffraction. Bioassay results showed that 1 exhibited good cytotoxic activity against two tumor cell lines B16 and HCT116. This study reported the single crystal data of 1 for the first time. The facile preparation of 1 afforded enough amount for its further biological evaluations.

引用

页码：48 / 50

页数：3

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