A facile preparation and crystal structure of romipeptide A

被引：0
|
作者：
Zhang, Hui [1 ,2 ]
Qi, Huan [3 ]
Duan, Wen-kai [2 ]
Zhang, Ji [1 ]
Wang, Ji-dong [3 ]
Xiang, Wen-sheng [1 ]
机构：
[1] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150030, Peoples R China
[2] Taizhou Vocat Coll Sci & Technol, Taizhou 318000, Peoples R China
[3] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2022年 / 75卷 / 01期
关键词：
DEPSIPEPTIDE; FK228;
D O I：
10.1038/s41429-021-00487-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A double disulfide tethering depsipeptide dimer, romipeptide A (1) was prepared by NaOH catalyzed dimerization of romidepsin. Its structure was determined by analysis of NMR and HR-ESI-MS data as well as single crystal X-ray diffraction. Bioassay results showed that 1 exhibited good cytotoxic activity against two tumor cell lines B16 and HCT116. This study reported the single crystal data of 1 for the first time. The facile preparation of 1 afforded enough amount for its further biological evaluations.
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收藏
页码：48 / 50
页数：3
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