Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertension

被引:73
|
作者
Farasat, S. Morteza [1 ,2 ,7 ]
Morrell, Christopher H. [1 ,3 ,7 ]
Scuteri, Angelo [4 ,7 ]
Ting, Chih-Tai [5 ,6 ,7 ]
Yin, Frank C. P. [7 ,8 ]
Spurgeon, Harold A. [1 ,7 ]
Chen, Chen-Huan [6 ,7 ]
Lakatta, Edward G. [1 ,7 ]
Najjar, Samer S. [1 ,7 ]
机构
[1] NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21225 USA
[2] NIA, Clin Res Branch, NIH, Baltimore, MD 21225 USA
[3] Loyola Coll, Dept Math Sci, Baltimore, MD 21210 USA
[4] Ist Nazl Ricovero E Cura Anziani, Unita Operat, Rome, Italy
[5] Natl Yang Ming Univ, Taipei 112, Taiwan
[6] Inst Clin Med & Cardiovasc Res Inst, Taipei 112, Taiwan
[7] Taichung Vet Gen Hosp, Taichung, Taiwan
[8] Washington Univ, Dept Biomed Engn, St Louis, MO USA
关键词
aorta; sinus of Valsalva; pulse pressure; systolic hypertension;
D O I
10.1161/HYPERTENSIONAHA.107.099515
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Hypertension accelerates the age-associated increase in aortic root diameter ( AoD), likely because of chronically elevated distending pressures. However, the pulsatile component of blood pressure may have a different relationship with AoD. We sought to assess the relationship between AoD and pulse pressure ( PP) while accounting for left ventricular and central arterial structural and functional properties, which are known to influence PP. The study population was composed of 1256 individuals, aged 30 to 79 years ( 48% women and 48% hypertensive), none of whom were on antihypertensive medications. Blood pressure was measured in the sitting position with conventional sphygmomanometry. PP was calculated as the difference between systolic and diastolic blood pressures. AoD was measured at end diastole at the level of the sinuses of Valsalva with echocardiography. The relationship between AoD and PP was evaluated with multiple regression analyses. PP was 50 +/- 14 mm Hg in men and 54 +/- 18 mm Hg in women, and AoD was 31.9 +/- 3.5 mm in men and 28.9 +/- 3.5 mm in women. After adjusting for age, age(2), height, weight, and mean arterial pressure, AoD was independently and inversely associated with PP in both sexes. After further adjustments for central arterial stiffness and wall thickness, reflected waves, and left ventricular geometry, AoD remained inversely associated with PP in both men ( coefficient =-0.48; P=0.0003; model R-2=0.51) and women ( coefficient =-0.40; P=0.01; model R-2=0.61). Thus, AoD is inversely associated with PP, suggesting that a small AoD may contribute to the pathogenesis of systolic hypertension. Longitudinal studies are needed to examine this possibility.
引用
收藏
页码:196 / 202
页数:7
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