Contribution of birth weight and adult waist circumference to cardiovascular disease risk in a longitudinal study

To determine the association of birth weight (BW) and waist circumference (WC) on cardiovascular disease (CVD). The longitudinal cohort study consisted of 745 participants who were able to provide their birth weight information and were followed from 2002 to 2014. During the follow-up, 83 events of CVD were confirmed. After adjusting for confounding factors, subjects with birth weight <2500 g were at a significantly increased CVD risk when compared to subjects with birth weight between 2500-3999 g (OR 2.47, 95% CI, 1.07-5.71). When high waist circumference (HWC), a measurement of adult obesity, was incorporated into stratifying factors according to presence or absence of low birth weight (LBW, birth weight <2500 g), adjusted CVD risk was significantly elevated in -LBW/+HWC group (OR 1.94, 95% CI, 1.10-3.43) and marginally significantly increased in +LBW/-HWC group (OR 2.94, 95% CI, 1.00-8.64). CVD risk was highest in subjects with LBW and HWC (+LBW/+HWC), OR 4.74 (95% CI, 1.48-15.21). Higher waist circumference in adulthood is an especially strong risk factor for cardiovascular disease among those small at birth. In this cohort, birth size and adiposity in adulthood interact to predict events of cardiovascular disease.