Severe jaundice, due to vanishing bile duct syndrome, as presenting symptom of Hodgkin's lymphoma, fully reversible after chemotherapy

被引:21
|
作者
Leeuwenburgh, Ivonne [1 ]
Lugtenburg, Elly P. J. [2 ]
van Buuren, Henk R. [1 ]
Zondervan, Pieter E. [3 ]
de Man, Rob A. [1 ]
机构
[1] Erasmus Univ, Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, NL-3015 GD Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr Rotterdam, Dept Hematol, NL-3015 GD Rotterdam, Netherlands
[3] Erasmus Univ, Med Ctr Rotterdam, Dept Pathol, NL-3015 GD Rotterdam, Netherlands
关键词
ductopenia; hepatotoxicity; Hodgkin's lymphoma; jaundice; vanishing bile duct syndrome; INTRAHEPATIC CHOLESTASIS; DISEASE; DIAGNOSIS;
D O I
10.1097/MEG.0b013e3282b9e6c2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Liver involvement in Hodgkin's lymphoma is common and is caused by hepatic infiltration, biliary obstruction by lymphoma, hepatitis, sepsis or complications of chemotherapeutic treatment. Jaundice caused by the vanishing bile duct syndrome related to Hodgkin's lymphoma is very rare. The mechanism is poorly understood but a paraneoplastic effect seems most likely as liver biopsy samples show cholestasis in the absence of lymphoma cells. Despite adequate treatment almost all reported patients died of liver failure or disease progression. Disease progression is explained partly by the difficulties encountered in the administration of potential hepatotoxic chemotherapy in severely cholestatic patients. We describe a 17-year-old man with vanishing bile duct syndrome and Hodgkin's lymphoma who was treated successfully with chemotherapy. The markedly elevated serum bilirubin levels completely normalized. Our case demonstrates that although dosing of chemotherapy in this situation can be very difficult, a good clinical outcome is possible, which makes the attempt at curative treatment worthwhile.
引用
收藏
页码:145 / 147
页数:3
相关论文
共 50 条
  • [21] Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review
    Mena Bakhit
    Thomas R McCarty
    Sunhee Park
    Basile Njei
    Margaret Cho
    Raffi Karagozian
    AnnMarie Liapakis
    World Journal of Gastroenterology, 2017, 23 (02) : 366 - 372
  • [22] Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review
    Bakhit, Mena
    McCarty, Thomas R.
    Park, Sunhee
    Njei, Basile
    Cho, Margaret
    Karagozian, Raffi
    Liapakis, AnnMarie
    WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (02) : 366 - 372
  • [23] Vanishing Bile Duct Syndrome in the Setting of Newly Diagnosed Hodgkin Lymphoma
    Muftah, Abdullah A.
    Waters, Rebecca
    Wang, Lan
    Zhang, Hao Chi
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2022, 117 (10): : S1992 - S1993
  • [24] Vanishing bile duct syndrome and immunodeficiency preceding the diagnosis of Hodgkin lymphoma
    Yeh, P.
    Lokan, J.
    Anantharajah, A.
    Grigg, A.
    INTERNAL MEDICINE JOURNAL, 2014, 44 (12A) : 1240 - 1244
  • [25] Vanishing Bile Duct Syndrome in a Hodgkin's Lymphoma Patient with Fatal Outcome Despite Lymphoma Remission
    Aleem, Aamer
    Al-Katari, Mohammad
    Alsaleh, Khalid
    AlSwat, Khalid
    Al-Sheikh, Abdulmalik
    SAUDI JOURNAL OF GASTROENTEROLOGY, 2013, 19 (06): : 286 - 289
  • [26] SEVERE PRURITUS AS A PRESENTING SYMPTOM OF HODGKIN'S LYMPHOMA
    Smith, R.
    May, K.
    Spriet, S.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2022, 129 : S154 - S154
  • [27] Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma: A Single Center Experience and Clinical Pearls
    Bakhit, Mena
    McCarty, Thomas R.
    Park, Sunhee
    Njei, Basile
    Cho, Margaret
    Karagozian, Raffi
    Liapakis, AnnMarie
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2016, 50 (08) : 688 - 688
  • [28] A rare presentation of vanishing bile duct syndrome in Hodgkin lymphoma: Case report
    Patodiya, Bharat
    Ramani, Vinod K.
    Rao, Padaki Nagaraja
    Sharma, Mithun
    Patodiya, Shalini
    Reddy, D. Nageshwar
    SAGE OPEN MEDICAL CASE REPORTS, 2023, 11
  • [29] VANISHING BILE DUCT SYNDROME: A PARANEOPLASTIC PHENOMENON SECONDARY TO OCCULT HODGKIN LYMPHOMA
    Keim, Lauren
    Cormier, Ian
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2020, 35 (SUPPL 1) : S609 - S610
  • [30] Vanishing Bile Duct Syndrome Following Cytomegalovirus Infection in a Child With Hodgkin Lymphoma
    Das, Anirban
    Mitra, Suvradeep
    Ghosh, Debjani
    Modi, Sheetal Kulkarni
    Roy, Paromita
    Das, Jayanta
    Bhattacharya, Sanjay
    Krishnan, Shekhar
    Das, Ashim
    Bhattacharyya, Arpita
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2018, 40 (01) : 83 - 84