TiCl4: An efficient catalyst for one-pot synthesis of 1,2-dihydro-1-aryl-naphtho-[1,2-e][1,3]oxazin-3-one derivatives and their drug score analysis

被引：9

作者：

Hunnur, Raveendra ^{[1
]}

Kamble, Ravindra ^{[2
]}

Dorababu, Atukuri ^{[2
]}

Kumar, B. Sunil ^{[3
]}

Bathula, Chinna ^{[4
]}

机构：

[1] APL Res Ctr, 313,Batchupally, Hyderabad 500072, Andhra Pradesh, India

[2] Karnataka Univ, Dept Studies Chem, Dharwad 58000, Karnataka, India

[3] NET Coll Pharm, Dept Pharmaceut Chem, Raichur 584103, Karnataka, India

[4] Korea Res Inst Chem Technol, Energy Mat Res Ctr, Daejeon 305600, South Korea

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2017年 / 10卷

关键词：

Oxazines; One-pot reaction; Lewis acid; Solvent free multi-component coupling reaction; SOLVENT-FREE CONDITIONS; 3-COMPONENT;

D O I：

10.1016/j.arabjc.2013.06.028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multi-component, economical and efficient synthesis of 1,2-dihydro-1-aryl-naphtho[1,2-e][1,3]-oxazin-3-one derivatives (4a-k) with an excellent yield is described through a one-pot condensation of beta-naphthol, aromatic aldehydes and urea in presence of catalytic amount of TiCl4 (10 mol%) under conventional heating and microwave irradiation. The role of catalyst in the conversion of reactants to the final compounds is described. All the compounds have been characterized by spectral (IR, H-1, C-13 NMR and Mass) and analytical data. The pharmacological parameters of title compounds were also analyzed for their bioavailability by Osiris property explorer. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S1760 / S1764

页数：5

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