Humoral immunity 5 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine

被引：36
|
作者：
Barreto, L.
Guasparini, R.
Meekison, W.
Noya, F.
Young, L.
Mills, E.
机构：
[1] Sanofi Pasteur Ltd, Toronto, ON M2R 3T4, Canada
[2] Fraser Hlth Authority, Surrey, BC V3X 3A4, Canada
[3] Westcoast Clin Res, Coquitlam, BC V3C 4J2, Canada
[4] Montreal Childrens Hosp, Div Infect Dis, Montreal, PQ H3H 1P3, Canada
来源：
VACCINE | 2007年 / 25卷 / 48期
关键词：
pertussis; vaccine; serology;
D O I：
10.1016/j.vaccine.2007.09.031
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Persistence of antibodies following a single dose of Tdap, vaccine (tetanus, diphtheria, and five-component acellular pertussis vaccine for use in individuals past childhood) was evaluated in a follow-up of adolescents (N = 324) and adults (N = 644) who had received Tdap in earlier clinical trials. Outcome measures were seroprotection (tetanus and diphtheria) or seropositivity (pertussis) and geometric mean titers. Humoral immune responses to all antigens were robust 1 month after initial immunization; antibodies exceeded pre-immunization levels 1, 3, and 5 years later. These data will contribute to selecting the optimal interval for booster doses of Tdap. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.
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页码：8172 / 8179
页数：8
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