Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells

被引：35
|
作者：
Mei, Chun-li [1 ]
Chen, Zhi-jian [1 ]
Liao, Yu-hua [1 ]
Wang, Yan-fu [1 ]
Peng, Hong-yu [1 ]
Chen, Yu [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Cardiol, Wuhan 430022, Hubei Province, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2007年 / 31卷 / 12期
关键词：
ATP binding cassette transporter A1; cholesterol content; tumour necrosis factor-alpha; interleukin-10; THP-1 macrophage-derived foam cells;
D O I：
10.1016/j.cellbi.2007.06.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It is suggested that cholesterol efflux mediated by ATP binding cassette transporter A1 (ABCA1) plays an important role in anti-atherogenesis. However, the effects of inflammatory cytokines on ABCA1 expression and cholesterol accumulation in foam cells are little known. This study investigates the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) on ABCA1 expression and cholesterol content in THP-1 macrophage-derived foam cells. ABCA1mRNA and protein levels were determined by RT-PCR and Western blot, respectively. The total cholesterol content in THP-1 macrophage-derived foam cells was detected by the zymochemistry method. Results revealed that TNF-alpha could increase cholesterol content by down-regulating ABCA1 expression in a time-dependent manner in THP-1 macrophage-derived foam cells, which may contribute to its pro-atherosclerotic effect. In addition IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression and inhibited the down-regulation of ABCA1 by TNF-alpha in THP-1 macrophage-derived foam cells, which may be one of the mechanisms of IL-10 contributing to its anti-atherosclerotic action. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1456 / 1461
页数：6
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