T-cell receptor-γ gene analysis in evolving to advancing cutaneous T-cell lymphoma

被引:0
|
作者
Foo, Christopher C. I.
Tang, Mark By
Chong, Tina K. L.
Sun, Yong-Jiang
Tan, Suat-Hoon
机构
[1] Natl Skin Ctr, Singapore 308205, Singapore
[2] Tan Tock Seng Hosp, Singapore, Singapore
关键词
follicular mucinosis; mycosis fungoides; Sezary syndrome;
D O I
10.1111/j.1440-0960.2007.00370.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The diagnosis of cutaneous T-cell lymphoma is often a challenge for the dermatopathologist. Early stages can mimic inflammatory dermatoses. Our aim was to explore the applicability of a standard T-cell receptor-gamma polymerase chain reaction in various subtypes of cutaneous T-cell lymphomas. Ninety-six biopsy specimens from 38 patients were selected. These included 72 specimens of mycosis fungoides, 12 specimens of non-mycosis fungoides T-cell lymphomas, and 12 specimens in which histology was non-specific or equivocal in patients who were later diagnosed to have lymphoma. T cell clones were detected in 53 of 72 specimens of mycosis fungoides and eight of 12 specimens of non-mycosis fungoides lymphomas. Of the 72 specimens of mycosis fungoides, T-cell clones were detected in eight of 10 specimens of mycosis fungoides-associated follicular mucinosis and pigmented purpura-like mycosis fungoides. Four specimens from the 12 prediagnostic for cutaneous T-cell lymphomas showed presence of T-cell clones, identical to subsequent clones detected when lymphoma was fully established. In specimens where histology is not diagnostic and T-cell receptor-gamma gene analysis is positive, patients should be followed up closely. T-cell receptor-gamma gene analysis is a useful adjunct to histological diagnosis of early stage and variant types of mycosis fungoides.
引用
收藏
页码:156 / 160
页数:5
相关论文
共 50 条
  • [41] Cutaneous T-cell Lymphoma
    Weiner, David M.
    Rook, Alain H.
    HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2024, 38 (05) : 1087 - 1110
  • [42] Cutaneous T-cell lymphoma
    Kotz, EA
    Anderson, D
    Thierst, BH
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2003, 17 (02) : 131 - 137
  • [43] Cutaneous T-cell lymphoma
    Weenig, RH
    Pittelkow, MR
    MAYO CLINIC PROCEEDINGS, 2003, 78 (08) : 1054 - 1055
  • [44] Cutaneous T-cell lymphoma
    Arora, Shalabh
    Gogia, Ajay
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2020, 152 (07) : 48 - 49
  • [45] ADULT T-CELL LEUKEMIA LYMPHOMA AND CUTANEOUS T-CELL LYMPHOMA - ARE THEY RELATED
    YAMADA, M
    TAKIGAWA, M
    IWATSUKI, K
    INOUE, F
    INTERNATIONAL JOURNAL OF DERMATOLOGY, 1989, 28 (02) : 107 - 113
  • [46] Silent T-cell receptor cutaneous T-cell lymphoma associated to a clonal plasma cell proliferation
    Caballero, Ana
    Novelli, Silvana
    Mozos, Anna
    Garcia Muret, Pilar
    Sierra, Jorge
    Briones, Javier
    HEMATOLOGY REPORTS, 2019, 11 (01) : 6 - 8
  • [47] Molecular analysis of T-cell receptor β genes in cutaneous T-cell lymphoma reveals Jβ1 bias
    Morgan, Suzanne M.
    Hodges, Elizabeth
    Mitchell, Tracey J.
    Harris, Susan
    Whittaker, Sean J.
    Smith, John L.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (08) : 1893 - 1899
  • [48] T-cell receptor clonality analyses using nanopore sequencing for cutaneous T-cell lymphoma
    Cieslak, Cassandra
    Rueckert, Christian
    Busche, Tobias
    Hain, Carsten
    Kalinowski, Joern
    Schaper-Gerhardt, Katrin
    Gutzmer, Ralf
    Stadler, Rudolf
    EUROPEAN JOURNAL OF CANCER, 2023, 190 : S27 - S27
  • [49] Reduced Overall T-Cell Receptor Diversity As an Indicator of Aggressive Cutaneous T-Cell Lymphoma
    Gleason, Laura
    Porcu, Pierluigi
    Nikbakht, Neda
    BLOOD, 2022, 140 : 3539 - 3540
  • [50] Primary Cutaneous T-cell Lymphoma With Coexpression of T-Cell Receptors αβ and γδ
    Parekh, Vishwas
    Shim, Eun-Hee
    Knapp, Charles F., III
    Hughey, Lauren
    Elmets, Craig A.
    McKay, Kristopher
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2016, 38 (01) : 66 - 72