A Dynamical Paradigm for Molecular Cell Biology

被引:42
|
作者
Tyson, John J. [1 ,2 ]
Novak, Bela [3 ]
机构
[1] Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA
[2] Virginia Tech, Acad Integrated Sci, Div Syst Biol, Blacksburg, VA 24061 USA
[3] Univ Oxford, Dept Biochem, Oxford, England
基金
美国国家卫生研究院; 英国生物技术与生命科学研究理事会;
关键词
BIFURCATION-ANALYSIS; MODEL; SWITCH; CYCLE; HYSTERESIS; ACTIVATION; FEEDBACK;
D O I
10.1016/j.tcb.2020.04.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The driving passion of molecular cell biologists is to understand the molecular mechanisms that control important aspects of cell physiology, but this ambition is often limited by the wealth of molecular details currently known about these mechanisms. Their complexity overwhelms our intuitive notions of how molecular regulatory networks might respond under normal and stressful conditions. To make progress we need a new paradigm for connecting molecular biology to cell physiology. We suggest an approach that uses precise mathematical methods to associate the qualitative features of dynamical systems, as conveyed by 'bifurcation diagrams', with 'signal-response' curves measured by cell biologists.
引用
收藏
页码:504 / 515
页数:12
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