Early Embryonic Lethality in Genetically Engineered Mice: Diagnosis and Phenotypic Analysis

被引：34

作者：

Papaioannou, V. E. ^{[1
]}

Behringer, R. R. ^{[2
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, Med Ctr, New York, NY 10032 USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

VETERINARY PATHOLOGY | 2012年 / 49卷 / 01期

基金：

美国国家卫生研究院;

关键词：

embryo lethality; embryonic development; mice; pre-implantation diagnosis; post-implantation;

D O I：

10.1177/0300985810395725

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Embryonic lethality is a common phenotype that occurs in mice that are homozygous for genetically engineered mutations. These phenotypes highlight the time and place that a gene is first required during embryogenesis. Early embryonic lethality (ie, before and up to mid-gestation) can be straightforward to analyze because the stage at which death occurs suggests why an embryo has failed. Here we summarize general strategies for analyzing early embryonic lethal phenotypes in genetically engineered mouse mutants.

引用

页码：64 / 70

页数：7

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