Diagnostic Utility of Pax8, Pax2, and NGFR Immunohistochemical Expression in Pediatric Renal Tumors

被引:13
|
作者
Arva, Nicoleta C. [1 ]
Bonadio, Jeffrey [2 ]
Perlman, Elizabeth J. [1 ]
Cajaiba, Mariana M. [1 ]
机构
[1] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pathol & Lab Med, 225 E Chicago Ave, Chicago, IL 60611 USA
[2] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA
关键词
pediatric renal tumor; Pax8; Pax2; nerve growth factor receptor; Wilms tumor; clear cell sarcoma of the kidney; CLEAR-CELL SARCOMA; LINEAGE SPECIFICATION; KIDNEY; GENES; IMMUNOREACTIVITY; MORPHOGENESIS; TISSUES; MARKER; LIM1;
D O I
10.1097/PAI.0000000000000520
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Pediatric renal tumors (PRT) with small round blue or spindle cell morphology can be diagnostically challenging and only a limited number of immunohistochemical markers have been documented to help in the diagnosis: paired box (Pax) 2 and nerve growth factor receptor (NGFR) positivity have been demonstrated in Wilms tumor (WT) and clear cell sarcoma of the kidney (CCSK), respectively. However, the immunohistochemical expression of these markers in other PRT remains unknown. This study investigated Pax8, Pax2, and NGFR immunophenotype in a large series of PRT. Pax8 and Pax2 showed an identical staining pattern, and were expressed in all (100%) WT while most CCSK were negative. All congenital mesoblastic nephromas, metanephric stromal tumors, primitive neuroectodermal tumors, desmoplastic small round blue cell tumors, most rhabdoid tumors, and synovial sarcomas were negative for Pax8. NGFR was expressed in 96% of CCSK (diffuse expression in 91%). Only a minority of WT stained for NGFR: 16% showed expression in the blastemal and 25% in the mesenchymal components. NGFR expression was noted in synovial sarcomas (67%, with diffuse expression seen in only 1 case, 8%), rhabdoid tumors (19%), cellular congenital mesoblastic nephromas (13%) and metanephric stromal tumors (12.5%). Primitive neuroectodermal tumors and desmoplastic small round blue cell tumors were negative for NGFR. In conclusion, Pax8/Pax2 and NGFR are sensitive markers for the diagnosis of WT and CCSK, respectively. However, their specificity is limited by variable reactivity within a subset of other renal neoplasms.
引用
收藏
页码:721 / 726
页数:6
相关论文
共 50 条
  • [41] Comparison of PAX6 and PAX8 as Immunohistochemical Markers for Pancreatic Neuroendocrine Tumors
    Jin-Ping Lai
    Richard B. Mertens
    James Mirocha
    Jamie Koo
    Mariza Venturina
    Fai Chung
    Allen B. Mendez
    Melissa Kahn
    Deepti Dhall
    Endocrine Pathology, 2015, 26 : 54 - 62
  • [42] Comparison of PAX6 and PAX8 as Immunohistochemical Markers for Pancreatic Neuroendocrine Tumors
    Lai, Jin-Ping
    Mertens, Richard B.
    Mirocha, James
    Koo, Jamie
    Venturina, Mariza
    Chung, Fai
    Mendez, Allen B.
    Kahn, Melissa
    Dhall, Deepti
    ENDOCRINE PATHOLOGY, 2015, 26 (01) : 54 - 62
  • [43] Diagnostic roles of PAX8 immunohistochemistry in ovarian tumors
    Kim, Jooyoung
    Kim, Nae Yu
    Pyo, Jung-Soo
    Min, Kyeung-Whan
    Kang, Dong-Wook
    PATHOLOGY RESEARCH AND PRACTICE, 2023, 250
  • [44] Analyses of Pax2 and Pax8 in maintaining oviduct epithelial homeostasis and fertility.
    Soofi, Abdulsalam
    Zahi, Yali
    Cho, Kathleen
    Dressler, Greg
    CLINICAL CANCER RESEARCH, 2020, 26 (13) : 30 - 31
  • [45] Pax2 and Pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
    Narlis, Melina
    Grote, David
    Gaitan, Yaned
    Boualia, Sami K.
    Bouchard, Maxime
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (04): : 1121 - 1129
  • [46] PAX2 expression in renal dysplasia
    Lee, Yoon Hee
    Jung, Woo Hee
    Hong, Soon Won
    Jeong, Hyeon Joo
    KOREAN JOURNAL OF PATHOLOGY, 2007, 41 (02) : 69 - 78
  • [47] The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma
    Ameli, Cytological -Pathologic Correlation Fereshteh
    Zahavi, Zahra
    Kosari, Farid
    Soleimani, Vahid
    ANNALS OF DIAGNOSTIC PATHOLOGY, 2022, 60
  • [48] PAX8 and PAX2 Expression in Endocervical Adenocarcinoma In-Situ and High-Grade Squamous Dysplasia
    Shukla, A.
    Thomas, D.
    Roh, M. H.
    LABORATORY INVESTIGATION, 2012, 92 : 296A - 296A
  • [49] PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis
    Bo Seong Yun
    Seyeon Won
    Ju-Hyun Kim
    Nara Lee
    Miseon Kim
    Mi Kyoung Kim
    Mi-La Kim
    Yong Wook Jung
    Ji Young Kim
    Seok Ju Seong
    Eunah Shin
    Journal of Ovarian Research, 15
  • [50] PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis
    Yun, Bo Seong
    Won, Seyeon
    Kim, Ju-Hyun
    Lee, Nara
    Kim, Miseon
    Kim, Mi Kyoung
    Kim, Mi-La
    Jung, Yong Wook
    Kim, Ji Young
    Seong, Seok Ju
    Shin, Eunah
    JOURNAL OF OVARIAN RESEARCH, 2022, 15 (01)