Applications of Exhaled Breath Condensate Analysis for Drug Monitoring and Bioequivalence Study of Inhaled Drugs

被引：0
|
作者：
Hashemzadeh, Nastaran [1 ,2 ]
Rahimpour, Elaheh [1 ,3 ]
Jouyban, Abolghasem [1 ,4 ,5 ,6 ]
机构：
[1] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[3] Tabriz Univ Med Sci, Infect & Trop Dis Res Ctr, Tabriz, Iran
[4] Shahid Beheshti Univ Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran
[5] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz 51664, Iran
[6] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran
来源：
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES | 2022年 / 25卷
关键词：
ESTABLISHING BIOEQUIVALENCE; PROPOFOL CONCENTRATIONS; PRODUCTS SIMILARITIES; LIQUID-CHROMATOGRAPHY; INHALATION TECHNIQUE; METHADONE; PHARMACOKINETICS; LAMOTRIGINE; PERFORMANCE; VERAPAMIL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
- The exhaled breath condensate (EBC) presents a simple and non-invasive alternative approach for bioequivalence assessments and therapeutic drug monitoring of inhaled drugs. EBC better represents the drug at the site of action and eliminates the possibility of the contribution of a swallowed portion of the dose when systemic bioavailability is used for assessment. This review summarizes the recently reported analytical methods for the quantification of drugs in EBC. It also discusses the difficulties in the bioequivalence evaluation criteria of generic orally inhaled drug products suggested by various regulatory agencies that may be eliminated using the EBC analysis approach.
引用
收藏
页码：391 / 401
页数：11
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