Histidylated cationic polyorganophosphazene/DNA self-assembled nanoparticles for gene delivery

被引：23
|
作者：
Yang, Yongxin [1 ,2 ]
Xu, Zhenghong [1 ]
Chen, Shangwei [3 ]
Gao, Yu [1 ]
Gu, Wangwen [1 ]
Chen, Lingli [1 ]
Pei, Luanying [2 ]
Li, Yaping [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
[2] Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200032, Peoples R China
[3] Testing & Anal Ctr S Yangtze Univ, Wuxi 214122, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 353卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
polyphosphazene; histidine; cytotoxicity; gene delivery;
D O I：
10.1016/j.ijpharm.2007.11.041
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cationic polyorganophosphazene has shown the ability to deliver gene. To obtain more efficient transfection, His(Boc)-OMe bearing histidine moiety was introduced to synthesize a new derivative of cationic polyphosphazenes with another side group of 2-dimethylaniinoethylamine (DMAEA). The poly(DMAEA/His(Boc)-OMe)phosphazene (PDHP) and DNA could self-assemble into nanoparticles with a size around 110 nm and zeta potential of +15 mV at the PDHP/DNA ratio of 10:1 (w/w). The maximum transfection efficiency of PDHP/DNA self-assembled nanoparticles (PHSNs) against 293 T cells was much higher than that of poly(di-2-dimethylan-noethylamine) phosphazenes (PDAP)/DNA self-assembled nanoparticles (PASNs) and PEI 25/DNA self-assembled nanoparticles (PESNs) at the polymer/DNA ratio of 10: 1, but the cytotoxicity of PDHP assayed by MTT was much lower than that of PDAP and PEI 25. These results suggested that PDHP could be a good candidate with high transfection efficiency and low cytotoxicity for gene delivery. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：277 / 282
页数：6
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