A three-component approach to isoxazolines and isoxazoles under metal-free conditions

被引：27
|
作者：
Wang, Dahan [1 ]
Zhang, Feng [2 ]
Xiao, Fuhong [1 ]
Deng, Guo-Jun [1 ]
机构：
[1] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Key Lab Green Organ Synth & Applicat, Xiangtan 411105, Peoples R China
[2] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 41期
基金：
中国国家自然科学基金;
关键词：
TERT-BUTYL NITRITE; PALLADIUM(II)-CATALYZED DIRECT CONVERSION; BOND OXIDATIVE FUNCTIONALIZATION; 1,3-DIPOLAR CYCLOADDITION; 3,5-DISUBSTITUTED ISOXAZOLES; ALKENES; OXIDES; GENERATION; ACCESS; DERIVATIVES;
D O I：
10.1039/c9ob01909j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed. In this protocol, TBN serves as a convenient N-O source to convert 2-methylquinoline into intermediate nitrile oxides in situ.
引用
收藏
页码：9163 / 9168
页数：6
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