Three-component synthesis of α-indole-β-sulfonyl tetrahydrofurans under metal-free conditions

被引：1
|
作者：
Xu, Haopeng
Pi, Chao [1 ]
Wu, Yangjie
Cui, Xiuling [1 ]
机构：
[1] Zhengzhou Univ, Coll Chem, Zhengzhou 450052, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2022年 / 46卷 / 05期
关键词：
C-H FUNCTIONALIZATION; HIGHLY SUBSTITUTED TETRAHYDROFURANS; STEREOSELECTIVE-SYNTHESIS; DIRECT ARYLATION; SATURATED HETEROCYCLES; ETHERS; CARBON; CARBOETHERIFICATION; CYCLIZATIONS; AMINATION;
D O I：
10.1039/d1nj05749a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient multi-component reaction has been developed for the synthesis of 2,3-disubstituted tetrahydrofurans in a "one pot" manner, starting from readily available 2-arylindoles, arylsulfonyl azides, and tetrahydrofuran under simple and easily operated reaction conditions. This process provides a wide array of alpha-indole-beta-sulfonyl tetrahydrofurans in good yields with excellent selectivity, avoiding the use of various additives and transition metals as catalysts.
引用
收藏
页码：2239 / 2244
页数：6
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