Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of Mycobacterium tuberculosis

被引：34

作者：

Muthukrishnan, M. ^{[1
]}

Mujahid, M. ^{[1
]}

Yogeeswari, P. ^{[2
]}

Sriram, D. ^{[2
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

[2] Birla Inst Technol & Sci Pilani, TB Drug Discovery Lab, Pharm Grp, Hyderabad 500078, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 18期

关键词：

Click chemistry; Spirochromones; Antitubercular activity; Mycobacterium tuberculosis; NATURAL-PRODUCTS; CLICK CHEMISTRY; REARRANGEMENT; FLAVANONES;

D O I：

10.1016/j.tetlet.2011.02.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2387 / 2389

页数：3

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