Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of Mycobacterium tuberculosis

被引：34
|
作者：
Muthukrishnan, M. [1 ]
Mujahid, M. [1 ]
Yogeeswari, P. [2 ]
Sriram, D. [2 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
[2] Birla Inst Technol & Sci Pilani, TB Drug Discovery Lab, Pharm Grp, Hyderabad 500078, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 18期
关键词：
Click chemistry; Spirochromones; Antitubercular activity; Mycobacterium tuberculosis; NATURAL-PRODUCTS; CLICK CHEMISTRY; REARRANGEMENT; FLAVANONES;
D O I：
10.1016/j.tetlet.2011.02.099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2387 / 2389
页数：3
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