Diastereoselective addition of silyl metals to γ-alkoxy substituted α,β-unsaturated esters

被引：3

作者：

Krief, A

Dumont, W

Baillieul, D

机构：

[1] Fac Univ Notre Dame Paix, Dept Chem, Lab Chim Organ Synth, B-5000 Namur, Belgium

[2] Fonds Format Rech Ind & Agr, B-1000 Brussels, Belgium

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 06期

关键词：

D O I：

10.1016/j.tetlet.2004.12.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dimethylphenylsilyllithium adds to Z-gamma-alkoxy-alpha,beta-unsaturated esters to produce almost exclusively (i) the anti-adducts when the reaction is carried out in THF and (ii) the anti-adduct when carried out in the presence of HMPA. Poor stereocontrol is achieved with stereoisomeric E-gamma-alkoxy-alpha,beta-unsaturated esters. (C) 2004 Published by Elsevier Ltd.

引用

页码：951 / 953

页数：3

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