Reinvestigation of the Synthesis of Isoliquiritigenin: Application of Horner-Wadsworth-Emmons Reaction and Claisen-Schmidt Condensation

被引：8

作者：

Sano, Shigeki ^{[1
]}

Okubo, Yoshinori ^{[1
]}

Handa, Atsushi ^{[1
]}

Nakao, Michiyasu ^{[1
]}

Kitaike, Syuji ^{[1
]}

Nagao, Yoshimitsu ^{[1
]}

Kakegawa, Hisao ^{[2
]}

机构：

[1] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan

[2] Kagawa Univ, Fac Engn, Kagawa 7610396, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 07期

关键词：

isoliquiritigenin; chalcone; Horner-Wadsworth-Emmons reaction; Claisen-Schmidt condensation; cis-trans isomerization; PROSTATE-CANCER; CELLS; DERIVATIVES; EXPRESSION; FLAVONOIDS; CATALYST;

D O I：

10.1248/cpb.59.885

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Isoliquiritigenin [ILG, (E)-1] was readily prepared via the Horner-Wadsworth-Emmons reactions using beta-ketophosphonates 5a, b. An improved protocol for the synthesis of (E)-1 via the Claisen-Schmidt condensation was also presented.

引用

页码：885 / 888

页数：4

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