The Oral Selective Inhibitor of Nuclear Export ( SINE) Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin's Lymphoma (NHL)

被引:0
|
作者
Kuruvilla, John [1 ]
Byrd, John C. [2 ]
Flynn, Joseph M. [3 ]
Garzon, Ramiro [3 ]
Porcu, Pierluigi [2 ]
Wagner-Johnston, Nina [4 ]
Savoie, Mary Lynn [5 ]
Stone, Richard M. [6 ]
Jacobsen, Eric D. [6 ]
Mau-Sorensen, Morten [7 ]
Brown, Peter de Nully [8 ]
Baz, Rachid [9 ]
Shal, Bijal [9 ]
Flinn, Ian [10 ]
Gabrail, Nashat [11 ]
Kukreti, Vishal [12 ]
Tiedemann, Rodger E. [12 ]
Landesman, Yosef [13 ]
Klebanov, Boris [13 ]
Shacham, Eran [13 ]
Saint-Martin, Jean-Richard [13 ]
Marshall, Tracey [13 ]
McCartney, John [13 ]
McCauley, Dilara [13 ]
Carlson, Robert [13 ]
Norori, Sasha [14 ]
Savona, Michael R. [13 ]
Rashal, Tami [13 ]
Mirza, Mansoor R. [13 ]
Kauffman, Michael [13 ]
Shacham, Sharon [13 ]
机构
[1] Univ Toronto, Princess Margaret Canc Ctr, Toronto, ON, Canada
[2] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[4] Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO USA
[5] Alberta Hlth Serv, Calgary, AB, Canada
[6] Dana Farber Canc Inst, Boston, MA 02115 USA
[7] Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark
[8] Rigshosp, DK-2100 Copenhagen, Denmark
[9] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
[10] Sarah Cannon Res Inst, Nashville, TN USA
[11] Gabrail Canc Ctr, Canton, OH USA
[12] Princess Margaret Canc Ctr, Toronto, ON, Canada
[13] Karyopharm Therapeut Inc, Newton, MA USA
[14] Ozmosis Res Inc, Toronto, ON, Canada
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [21] Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer
    Kazim, Sabiha
    Malafa, Mokenge P.
    Coppola, Domenico
    Husain, Kazim
    Zibadi, Sherma
    Kashyap, Trinayan
    Crochiere, Marsha
    Landesman, Yosef
    Rashal, Tami
    Sullivan, Daniel M.
    Mahipal, Amit
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (07) : 1570 - 1581
  • [22] Selinexor (KPT-330), an oral Selective Inhibitor of Nuclear Export (SINE) compound, in combination with FOLFOX in patients with metastatic colorectal cancer (mCRC) - final results of the phase I SENTINEL trial
    Nilsson, S.
    Stein, A.
    Rolfo, C.
    Kranich, A.
    Quidde, J.
    Papadimitriou, K.
    Theile, S.
    Amberg, S.
    Bokemeyer, C.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 122 - 122
  • [23] Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL
    Nilsson, Sven
    Stein, Alexander
    Rolfo, Christian
    Kranich, Anne L.
    Mann, Julia
    Papadimitriou, Konstantinos
    Theile, Susann
    Amberg, Stefanie
    Bokemeyer, Carsten
    CURRENT CANCER DRUG TARGETS, 2020, 20 (10) : 811 - 817
  • [24] Nuclear export inhibitor selinexor (KPT-330) demonstrates anti-tumor efficacy alone and in combination with chemotherapy in multiple breast cancer models
    Arango, Natalia Paez
    Evans, Kurt
    Zhao, Ming
    Yuca, Erkan
    Scott, Stephen
    Kim, Charissa
    Naing, Aung
    Meric-Bernstam, Funda
    CANCER RESEARCH, 2016, 76
  • [25] A phase 1b food effect study of the first-in-class, oral, selective inhibitor of nuclear export (SINE) selinexor (KPT-330) in patients (pts) with advanced sarcomas.
    Gounder, Mrinal M.
    Loong, Herbert H. F.
    Nyquist-Schultz, Kjirsten
    Baker, Stephanie
    Ustoyev, Yelena
    Tanner, Lanier R.
    Shacham, Sharon
    McCauley, Dilara
    Rashal, Tami
    Saint-Martin, Jean-Richard
    Shacham, Eran
    Friedlander, Sharon
    Tamir, Sharon
    Marshall, Tracey
    Landesman, Yosef
    Kauffman, Michael
    Rebello, Sasha
    Mirza, Mansoor Slide Raza
    Schwartz, Gary K.
    Razak, Albiruni R. A.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [26] THE COMBINATION OF SELINEXOR (KPT-330), A SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE), & THE FLT3 INHIBITOR QUIZATINIB SHOWS ANTI-TUMOR ACTIVITY IN ACUTE MYELOID LEUKEMIA (AML) IN VITRO AND IN VIVO
    Carlson, R.
    Senapedis, W.
    Landesman, Y.
    Shacham, S.
    HAEMATOLOGICA, 2014, 99 : 290 - 291
  • [27] Selective Inhibitor of Nuclear Export Selinexor (KPT-330) and BCL2 Inhibitor ABT-199 Enhance the Anti-Lymphoma Effect of BTK Inhibitor Ibrutinib in Mantle Cell Lymphoma
    Tabe, Yoko
    Harada, Masako
    Miyamae, Yuka
    Kazuno, Saiko
    Fujimura, Tsutomu
    Ueno, Takashi
    Miida, Takashi
    Konopleva, Marina
    Andreeff, Michael
    BLOOD, 2014, 124 (21)
  • [28] TOPICAL SELINEXOR (KPT-330), A SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) SHOWS INCREASED BLOOD FLOW AND ACCELERATED HEALING USING NONINVASIVE TECHNIQUES IN AN ISCHEMIC MODEL OF WOUND HEALING
    Ganesh, K.
    Kitsos, C.
    Rashal, T.
    Roy, S.
    Gnyawali, S.
    Friedlander, S.
    Chen, W.
    Ellis, J.
    Austad, B.
    McCauley, D.
    Kauffman, M.
    Shacham, S.
    Sen, C.
    WOUND REPAIR AND REGENERATION, 2015, 23 (02) : A22 - A22
  • [29] KCP-330-005/SIGN: A PHASE II, OPEN-LABEL STUDY OF EFFICACY AND SAFETY OF THE SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) KPT-330 (SELINEXOR) IN PATIENTS WITH ADVANCED GYNAECOLOGIC MALIGNANCIES
    Vergote, I.
    Lund, B.
    Ujmajuridze, Z.
    Havsteen, H.
    Rashal, T.
    Marshall, T.
    McCartney, J.
    Kauffman, M.
    Shacham, S.
    Mirza, M. R.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2014, 24 (09) : 1182 - 1183
  • [30] Preclinical activity in non-Hodgkin's lymphoma of Selinexor, a selective inhibitor of nuclear export (SINE), is enhanced through combination with standard-of-care therapies
    Azmi, Asfar S.
    Aboukameel, Amro
    Carlson, Robert O.
    Elloul, Sivan
    Shacham, Sharon
    Kauffman, Michael
    Frenkel, Ran
    Mohammad, Ramzi M.
    CANCER RESEARCH, 2015, 75