The Oral Selective Inhibitor of Nuclear Export ( SINE) Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin's Lymphoma (NHL)

被引：0

作者：

Kuruvilla, John ^{[1
]}

Byrd, John C. ^{[2
]}

Flynn, Joseph M. ^{[3
]}

Garzon, Ramiro ^{[3
]}

Porcu, Pierluigi ^{[2
]}

Wagner-Johnston, Nina ^{[4
]}

Savoie, Mary Lynn ^{[5
]}

Stone, Richard M. ^{[6
]}

Jacobsen, Eric D. ^{[6
]}

Mau-Sorensen, Morten ^{[7
]}

Brown, Peter de Nully ^{[8
]}

Baz, Rachid ^{[9
]}

Shal, Bijal ^{[9
]}

Flinn, Ian ^{[10
]}

Gabrail, Nashat ^{[11
]}

Kukreti, Vishal ^{[12
]}

Tiedemann, Rodger E. ^{[12
]}

Landesman, Yosef ^{[13
]}

Klebanov, Boris ^{[13
]}

Shacham, Eran ^{[13
]}

Saint-Martin, Jean-Richard ^{[13
]}

Marshall, Tracey ^{[13
]}

McCartney, John ^{[13
]}

McCauley, Dilara ^{[13
]}

Carlson, Robert ^{[13
]}

Norori, Sasha ^{[14
]}

Savona, Michael R. ^{[13
]}

Rashal, Tami ^{[13
]}

Mirza, Mansoor R. ^{[13
]}

Kauffman, Michael ^{[13
]}

Shacham, Sharon ^{[13
]}

机构：

[1] Univ Toronto, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA

[3] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[4] Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO USA

[5] Alberta Hlth Serv, Calgary, AB, Canada

[6] Dana Farber Canc Inst, Boston, MA 02115 USA

[7] Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark

[8] Rigshosp, DK-2100 Copenhagen, Denmark

[9] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[10] Sarah Cannon Res Inst, Nashville, TN USA

[11] Gabrail Canc Ctr, Canton, OH USA

[12] Princess Margaret Canc Ctr, Toronto, ON, Canada

[13] Karyopharm Therapeut Inc, Newton, MA USA

[14] Ozmosis Res Inc, Toronto, ON, Canada

来源：

BLOOD | 2014年 / 124卷 / 21期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 50 条

[1] A phase 1 dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with heavily pretreated non-Hodgkin lymphoma (NHL).
Gutierrez, Martin
Goy, Andre
Byrd, John C.
Flynn, Joseph M.
Sorensen, Morten
Brown, Peter
Gabrail, Nashat Y.
Savona, Michael
Flinn, Ian
Baz, Rachid C.
Shah, Bijal D.
Stone, Richard M.
Jacobsen, Eric
Kukreti, Vishal
Tiedemann, Roger E.
Rashal, Tami
Mirza, Mansoor Raza
Shacham, Sharon
Kauffman, Michael
Kuruvilla, John
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[2] Safety, Efficacy, and Determination of the Recommended Phase 2 Dose for the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330)
Chen, Christine
Garzon, Ramiro
Gutierrez, Martin
Jacoby, Meagan A.
Brown, Peter
Flinn, Ian
Stone, Richard M.
Savoie, Mary Lynn
Baz, Rachid
Gabrail, Nashat Y.
Wang, Michael
Martin, Peter
Siegel, David
Mau-Sorensen, Morten
Andreef, Michael
Marshall, Tracey
Saint-Martin, Jean-Richard
Carlson, Robert
Shacham, Sharon
Kauffman, Michael
Kuruvilla, John
BLOOD, 2015, 126 (23)
[3] Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Of a First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin's Lyphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Kuruvilla, John
Gutierrez, Martin
Shah, Bijal D.
Gabrail, Nashat Y.
Brown, Peter de Nully
Stone, Richard M.
Garzon, Ramiro
Savona, Michael
Siegel, David S.
Baz, Rachid
Mau-Sorensen, Morten
Davids, Matthew S.
Byrd, John C.
Shacham, Sharon
Rashal, Tami
Yau, Cindy Y. F.
McCauley, Dilara
Saint-Martin, Jean-Richard
McCartney, John
Landesman, Yosef
Klebanov, Boris
Pond, Greg
Oza, Amit M.
Kauffman, Michael
Mirza, Mansoor R.
BLOOD, 2013, 122 (21)
[4] Preclinical efficacy of the novel, oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) on castration resistant prostate cancer
Maity, Sankar Narayan
Wu, Guanglin
Lu, Jing-Fang
Hoang, Anh
Landesman, Yosef
McCauley, Dilara
Shacham, Sharon
Kauffman, Michael G.
Aparicio, Ana M.
Efstathiou, Eleni
Araujo, John C.
Logothetis, Christopher J.
CANCER RESEARCH, 2014, 74 (19)
[5] A PHASE 1 DOSE ESCALATION STUDY OF THE ORAL SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) SELINEXOR (KPT-330) IN PATIENTS (PTS) WITH RELAPSED / REFRACTORY ACUTE MYELOID LEUKEMIA (AML)
Garzon, R.
Flinn, I.
Berdeja, J.
DeAngelo, D.
Wadleigh, M.
Yee, K.
Schuh, A.
Mau-Sorensen, M.
Brown, P.
Lancet, J.
Shah, B.
Gutierrez, M.
Gabrail, N.
Wagner-Johnston, N.
Blum, W.
Carlson, R.
Klebanov, B.
McCauley, D.
Shacham, E.
McCartney, J.
Marshall, T.
Saint-Martin, J. R.
Rebello, S.
Rashal, T.
Kauffman, M.
Shacham, S.
Mirza, M.
Stone, R.
HAEMATOLOGICA, 2014, 99 : 527 - 528
[6] A phase I dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with relapsed/refractory acute myeloid leukemia (AML).
Yee, Karen W. L.
Savona, Michael
Sorensen, Morten
Brown, Peter
Blum, William G.
DeAngelo, Daniel J.
Gutierrez, Martin
Garzon, Ramiro
Schuh, Andre C.
Gabrail, Nashat Y.
Wadleigh, Martha
Lancet, Jeffrey E.
Shah, Bijal D.
Berdeja, Jesus G.
Wagner-Johnston, Nina D.
Flinn, Ian
Rashal, Tami
Kauffman, Michael
Shacham, Sharon
Stone, Richard M.
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[7] Phase II Results of Ara-C and Idarubicin in Combination with the Selective Inhibitor of Nuclear Export (SINE) Compound Selinexor (KPT-330) in Patients with Relapsed or Refractory AML
Fiedler, Walter
Heuser, Michael
Chromik, Joerg
Thol, Felicitas
Bokemeyer, Carsten
Theile, Susann
Lebkuechner, Isabell
Kranich, Anne L.
BLOOD, 2016, 128 (22)
[8] Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells
Etchin, Julia
Bonnie Thi Le
Kentsis, Alex
Mansour, Marc R.
Berezovskaya, Alla
Stone, Richard M.
Galinsky, Ilene
DeAngelo, Daniel J.
McCauley, Dilara
Kauffman, Michael
Shacham, Sharon
Wang, Jean C. Y.
Kung, Andrew L.
Look, A. Thomas
BLOOD, 2014, 124 (21)
[9] Preclinical Effect of Selinexor (KPT-330), a Selective Inhibitor of Nuclear Export, in Pediatric Rhabdoid Tumors
Marks, L.
Diolaiti, D.
Mundi, P.
Gaviria, E.
Rainey, A.
Dela Cruz, F.
Andreas, C.
Kung, A.
PEDIATRIC BLOOD & CANCER, 2018, 65 : S394 - S395
[10] PRELIMINARY PHASE II RESULTS OF ARA-C AND IDARUBICIN IN COMBINATION WITH SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) COMPOUND SELINEXOR (KPT-330) IN PATIENTS WITH RELAPSED OR REFRACTORY AML
Fiedler, W.
Heuser, M.
Ottmann, O.
Kebenko, M.
Thol, F.
Trummer, A.
Brandts, C.
Bokemeyer, C.
Theile, S.
Kranich, A.
HAEMATOLOGICA, 2015, 100 : 221 - 221

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