Synthesis of 4-(2-(piperazin-1-yl)-7,8-dihydro-5H-thiopyrano[4,3-d] pyrimidin-4-yl)morpholine and 4-morpholino-2-(piperazin-1-yl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine 6,6-dioxide

被引：1
|
作者：
Xu, Shan [1 ]
Sun, Chengyu [1 ]
Lei, Fei [1 ]
Tu, Yuanbiao [1 ]
Zeng, Weipeng [1 ]
Xia, Hui [1 ]
Zheng, Pengwu [1 ]
Zhu, Wufu [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Peoples R China
来源：
MATERIAL SCIENCE, CIVIL ENGINEERING AND ARCHITECTURE SCIENCE, MECHANICAL ENGINEERING AND MANUFACTURING TECHNOLOGY II | 2014年 / 651-653卷
关键词：
PI3K/mTOR ihhibitors; Thiopyrano[4,3-d]pyrimidine derivatives; Synthesis;
D O I：
10.4028/www.scientific.net/AMM.651-653.111
中图分类号：
TU [建筑科学];
学科分类号：
0813 ;
摘要：
Two novel thiopyrano[4,3-d]pyrimidine derivatives 7 and 8 were synthesized from dimethyl 3,3'-thiodipropanoate through six steps including two times of cyclization, chlorination, oxidation, substitution with morpholine and piperazine and their structures were confirmed by H-1 NMR and MS spectrum. The total yield of the six steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropanoate). The synthetic routes of them can be used to synthesize PI3K/mTOR inhibitors bearing a thiopyrano[4,3-d] pyrimidine nucleus.
引用
收藏
页码：111 / 114
页数：4
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