The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: Molecular target on cancer metabolism

被引：30

作者：

Yu, Woo Sik ^{[1
]}

Jeong, Soo-Jin ^{[1
]}

Kim, Ji-Hyun ^{[1
]}

Lee, Hyo-Jung ^{[1
]}

Song, Hyo Sook ^{[1
]}

Kim, Min-Seok ^{[2
]}

Ko, Eunjung ^{[1
]}

Lee, Hyo-Jeong ^{[1
]}

Khil, Jae-Ho ^{[3
]}

Jang, Hyeung-Jin ^{[1
]}

Kim, Young Chul ^{[1
]}

Bae, Hyunsu ^{[1
]}

Chen, Chang Yan ^{[4
]}

Kim, Sung-Hoon ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Oriental Med, Canc Prevent Mat Dev Res Ctr, Seoul 130701, South Korea

[2] Tufts Univ, Coll Dent Med, Boston, MA 02111 USA

[3] Kyung Hee Univ, Coll Phys Educ, Seoul 130701, South Korea

[4] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

来源：

MOLECULES AND CELLS | 2011年 / 32卷 / 02期

关键词：

cancer metabolism; MDA-MB-231; microarray; PGG; real-time PCR; BETA-D-GLUCOSE; CATECHOL-O-METHYLTRANSFERASE; ACETYL-COA CARBOXYLASE; ALDEHYDE DEHYDROGENASE; IN-VITRO; GENE-EXPRESSION; DOWN-REGULATION; TUMOR-GROWTH; INHIBITION; APOPTOSIS;

D O I：

10.1007/s10059-011-2254-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphenolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer cells by using Illumina Human Ref-8 expression BeadChip assay. Through the Beadstudio v3 micro assay program to compare the identified genes expressed in PGG-treated MDA-MB-231 cells with untreated control, we found several unique genes that are closely associated with pyruvate metabolism, glycolysis/gluconeogenesis and tyrosine metabolism, including PC, ACSS2, ACACA, ACYP2, ALDH3B1, FBP1, PRMT2 and COMT. Consistent with microarray data, real-time RT-PCR confirmed the significant down-regulation of these genes at mRNA level in PGG-treated MDA-MB-231 cells. Our findings suggest the potential of PGG as anticancer agent for breast cancer cells by targeting cancer metabolism genes.

引用

页码：123 / 132

页数：10

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