Synthesis of Indolizines through Oxidative Linkage of C-C and C-N Bonds from 2-Pyridylacetates

被引：44

作者：

Mohan, Darapaneni Chandra ^{[1
]}

Ravi, Chitrakar ^{[1
]}

Pappula, Venkatanarayana ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] CSIR Cent Salt & Marine Chem Res Inst, Acad Sci & Innovat Res, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 13期

关键词：

ONE-POT; MULTICOMPONENT SYNTHESIS; CYCLIZATION; KETONES; FUNCTIONALIZATION; DERIVATIVES; ANNULATION; ALKYNES; IODINE; 2-ALKYLAZAARENES;

D O I：

10.1021/acs.joc.5b00477

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of indolizine-1-carboxylates through the Ortoleva-King reaction of 2-pyridylacetate followed by the Aldol condensation under mild reaction conditions has been described. This protocol is compatible with a broad range of functional groups, and it has been also successfully extended to unsaturated ketones, bringing about the regioselective formation of benzoyl-substituted indolizines through Michael addition followed by C-N bond formation, which are difficult to prepare by previous methods in a single step.

引用

页码：6846 / 6855

页数：10

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