Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis

被引：58
|
作者：
Schwartz, Noa
Michaelson, Jennifer S.
Putterman, Chaim
机构：
[1] Albert Einstein Coll Med, Div Rheumatol, Bronx, NY 10461 USA
[2] Biogen Idec Inc, Cambridge, MA USA
来源：
AUTOIMMUNITY, PART A: BASIC PRINCIPLES AND NEW DIAGNOSTIC TOOLS | 2007年 / 1109卷
关键词：
systemic lupus erythematosus; lupus nephritis; biomarkers; TWEAK; Lipocalin-2;
D O I：
10.1196/annals.1398.032
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.
引用
收藏
页码：265 / 274
页数：10
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