Exploiting Post-mitotic Yeast Cultures to Model Neurodegeneration

被引:13
|
作者
Ruetenik, Andrea [1 ,2 ]
Barrientos, Antonio [1 ,2 ,3 ]
机构
[1] Univ Miami, Miller Sch Med, Sch Med, Dept Neurol, Miami, FL 33136 USA
[2] Univ Miami, Miller Sch Med, Sch Med, Neurosci Grad Program, Miami, FL 33136 USA
[3] Univ Miami, Miller Sch Med, Sch Med, Dept Biochem, Miami, FL 33136 USA
来源
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2018年 / 11卷
关键词
inducible yeast model; Saccharomyces cerevisiae; chronological life span; neurodegenerative disorder; mitochondria; proteotoxicity; reactive oxygen species; CHRONOLOGICAL LIFE-SPAN; ALPHA-SYNUCLEIN TOXICITY; MUTANT HUNTINGTIN FRAGMENT; SACCHAROMYCES-CEREVISIAE STRAINS; MITOCHONDRIAL-DNA DELETIONS; SUBSTANTIA-NIGRA NEURONS; PICK TYPE C1; OXIDATIVE STRESS; STATIONARY-PHASE; CALORIE RESTRICTION;
D O I
10.3389/fnmol.2018.00400
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Over the last few decades, the budding yeast Saccharomyces cerevisiae has been extensively used as a valuable organism to explore mechanisms of aging and human age-associated neurodegenerative disorders. Yeast models can be used to study loss of function of disease-related conserved genes and to investigate gain of function activities, frequently proteotoxicity, exerted by non-conserved human mutant proteins responsible for neurodegeneration. Most published models of proteotoxicity have used rapidly dividing cells and suffer from a high level of protein expression resulting in acute growth arrest or cell death. This contrasts with the slow development of neurodegenerative proteotoxicity during aging and the characteristic post-mitotic state of the affected cell type, the neuron. Here, we will review the efforts to create and characterize yeast models of neurodegeneration using the chronological life span model of aging, and the specific information they can provide regarding the chronology of physiological events leading to neurotoxic proteotoxicity-induced cell death and the identification of new pathways involved.
引用
收藏
页数:18
相关论文
共 50 条
  • [31] In vivo base editing of post-mitotic sensory cells
    Yeh, Wei-Hsi
    Chiang, Hao
    Rees, Holly A.
    Edge, Albert S. B.
    Liu, David R.
    NATURE COMMUNICATIONS, 2018, 9
  • [32] INITIATION OF MITOSIS IN POST-MITOTIC NUCLEI OF PHYSARUM POLYCEPHALUM
    GUTTES, E
    GUTTES, S
    EXPERIENTIA, 1963, 19 (01): : 13 - &
  • [33] Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila
    Clemente, Giuliana D.
    Hannaford, Matthew R.
    Beati, Hamze
    Kapp, Katja
    Januschke, Jens
    Griffis, Eric R.
    Mueller, Hans-Arno J.
    JOURNAL OF DEVELOPMENTAL BIOLOGY, 2018, 6 (02):
  • [34] Optimization of an in vitro model for assessing the survival of post-mitotic photoreceptors and Muller glial cells
    Bolinches-Amoros, Arantxa
    Storm, Tina
    Russell, Angela J.
    Davies, Stephen G.
    Barnard, Alun R.
    MacLaren, Robert E.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2018, 59 (09)
  • [35] Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth
    Edgar, Bruce A.
    Zielke, Norman
    Gutierrez, Crisanto
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (03) : 197 - 210
  • [36] Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth
    Bruce A. Edgar
    Norman Zielke
    Crisanto Gutierrez
    Nature Reviews Molecular Cell Biology, 2014, 15 : 197 - 210
  • [37] Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell
    Martinez, Michael A. Q.
    Zhao, Chris Z.
    Moore, Frances E. Q.
    Yee, Callista
    Zhang, Wan
    Shen, Kang
    Martin, Benjamin L.
    Matus, David Q.
    DIFFERENTIATION, 2024, 137
  • [38] Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells
    Ghosh, PM
    Mott, GE
    GhoshChoudhury, N
    Radnik, RA
    Stapleton, ML
    Ghidoni, JJ
    Kreisberg, JI
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1997, 1359 (01): : 13 - 24
  • [39] Temporal transitions in the post-mitotic nervous system of Caenorhabditis elegans
    HaoSheng Sun
    Oliver Hobert
    Nature, 2021, 600 : 93 - 99
  • [40] Temporal transitions in the post-mitotic nervous system of Caenorhabditis elegans
    Sun, HaoSheng
    Hobert, Oliver
    NATURE, 2021, 600 (7887) : 93 - +