Novel and highly efficient one pot protocol for the synthesis of diversely functionalized triarylmethanes

被引：11
|
作者：
Babu, B. Madhu [1 ]
Thakur, Pramod B. [1 ]
Bangade, Vikas M. [1 ]
Meshram, H. M. [1 ]
机构：
[1] Indian Inst Chem Technol, Med Chem & Pharmacol Div, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 06期
关键词：
Triarylmethanes; Friedel-Crafts reaction; Oxidation; BF3 center dot OEt2; Lewis acid; ELECTRON-RICH ARENES; POLY(ETHYLENE GLYCOL)-SUPPORTED TEMPO; CATALYZED BAEYER CONDENSATION; FRIEDEL-CRAFTS ALKYLATIONS; COLUMN CHROMATOGRAPHY-FREE; 3-HYDROXY-2-OXINDOLE SCAFFOLDS; AROMATIC-ALDEHYDES; SELECTIVE ALKYLATION; ANTIVIRAL ACTIVITIES; OXIDATION;
D O I：
10.1016/j.tetlet.2014.11.139
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, convenient, and novel one pot approach is described for the synthesis of triarylmethanes by in situ oxidation of benzylalcohols followed by the Friedel-Crafts alkylation of di/trimethoxybenzenes in the presence of BF3 center dot OEt2. The generality of the present method is strengthened by screening a variety of aromatic, aliphatic, and heteroaromatic alcohols with methoxy arenes. Shorter reaction time, mild reaction condition, good yields, and wide scope of substrates are the significant features of this protocol. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：766 / 771
页数：6
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