Adverse drug reactions of montelukast: from theory to practice. Case report

被引：4
|
作者：
Caudevilla Lafuente, Pilar [1 ]
Garcia Iniguez, Juan P. [2 ]
Martin de Vicente, Carlos [3 ]
机构：
[1] Hosp Univ Miguel Servet, Serv Pediat, Zaragoza, Spain
[2] Hosp Univ Miguel Servet, Unidad Cuidados Intensivos Pediat, Zaragoza, Spain
[3] Hosp Univ Miguel Servet, Unidad Neumol Pediat, Zaragoza, Spain
来源：
ARCHIVOS ARGENTINOS DE PEDIATRIA | 2021年 / 119卷 / 04期
关键词：
Montelukast; leukotriene antagonists; drug-related side effects and adverse reactions; child; sleep initiation and maintenance disorders;
D O I：
10.5546/aap.2021.e357
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Montelukastis widely used in recurrent wheezing and/orasthma treatment. Several adverse drug reactions (ADRs) have been described in children related to montelukast. Neuropsychiatric reactions are one of the most important. We designed an observational, retrospective, descriptive study on ADRs related to montelukast in the Pediatric Pulmonology Unit, Hospital Universitario Miguel Servet, Zaragoza, Spain. Between January 2012 and December 2017, in the Pediatric Pulmonology Unit, 348 patients were treated with Montelukast; of them, 20 presented RAM. The main symptoms described were insomnia (n = 7), hyperactivity (n = 4), nightmares (n = 3), abdominal pain (n = 2) and paraesthesia in extremities (n = 2). They appeared from the first days to months after the start of treatment and disappeared after stopping it. Two patients presented limb paresthesia, not described previously in children. The 5.7 % of our patients treated with montelukast had ADRs that required treatment discontinuation. Sleep disorders were the most frequent.
引用
收藏
页码：E357 / E359
页数：3
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