New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

被引：13

作者：

Hou, Bolin ^{[1
]}

Liu, Sushi ^{[1
,2
]}

Huo, Ruiyun ^{[1
]}

Li, Yueqian ^{[1
,3
]}

Ren, Jinwei ^{[1
]}

Wang, Wenzhao ^{[1
]}

Wei, Tao ^{[2
]}

Jiang, Xuejun ^{[1
]}

Yin, Wenbing ^{[1
]}

Liu, Hongwei ^{[1
]}

Liu, Ling ^{[1
]}

Li, Erwei ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

[2] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

[3] Chinese Acad Sci, Inst Ctr Shared Technol & Facil, Inst Microbiol, Beijing 100101, Peoples R China

来源：

MARINE DRUGS | 2021年 / 19卷 / 07期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

mangrove-derived fungus; secondary metabolites; absolute configurations; bioactivity; BENZOFURANS; SPONGE;

D O I：

10.3390/md19070362

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A-D (4-7), together, with seven known metabolites (3 and 8-13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4 ' in 6 and C-9 in 7 were determined by [Rh-2(OCOCF3)(4)]-induced ECD spectra. Compound 1 showed moderate alpha-glucosidase inhibitory activities with IC50 values of 741.5 +/- 2.83 mu M. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 +/- 0.24 and 3.69 +/- 0.07 mu M, respectively.

引用

页数：13

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