1,2-Addition of Phenylacetylene to Aldimines Catalyzed by InCl3/CuCl in Water under Barbier Conditions

被引：13

作者：

Prajapati, Dipak ^{[1
]}

Sarma, Rupam ^{[1
]}

Bhuyan, Debajyoti ^{[1
]}

Hu, Wenhao ^{[2
]}

机构：

[1] CSIR NE Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India

[2] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

来源：

SYNLETT | 2011年 / 05期

关键词：

aldimines; water; indium chloride; copper chloride; propargylamines; ENANTIOSELECTIVE ALKYNE ADDITIONS; AQUEOUS-MEDIA; ORGANIC-REACTIONS; ORGANOMETALLIC REAGENTS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; AROMATIC KETONES; TERMINAL ALKYNES; PROPARGYLAMINES; ALDEHYDES;

D O I：

10.1055/s-0030-1259679

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient method for the preparation of various propargylamines has been achieved by the simple Barbier-Grignard-type reaction of phenylacetylene with a variety of aldimines under aqueous conditions, catalyzed by a bimetallic In-Cu system.

引用

页码：627 / 630

页数：4

共 38 条

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