A COST-EFFECTIVE PAPER-BASED SERS DEVICE FOR THE DETECTION OF CORTISOL IN SALIVA

被引：0

作者：

Agarwal, Dilip Kumar ^{[1
]}

Xia, Junfei ^{[1
]}

Sadeqi, Aydin ^{[1
]}

Owyeung, Rachel ^{[1
,2
]}

Nejad, Hojatollah R. ^{[1
]}

Sonkusale, Sameer ^{[1
,2
,3
]}

机构：

[1] Tufts Univ, Dept Elect & Comp Engn, Boston, MA 02111 USA

[2] Tufts Univ, Dept Chem & Biol Engn, Boston, MA 02111 USA

[3] Tufts Univ, Dept Biomed Engn, Boston, MA 02111 USA

来源：

2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS) | 2021年

基金：

美国国家科学基金会;

关键词：

Surface Enhanced Raman Spectroscopy; Gold Nanoparticles; Lateral Flow SERS; Detection; Cortisol; Saliva; Paper; ELECTROCHEMICAL DETECTION;

D O I：

10.1109/TRANSDUCERS50396.2021.9495649

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Cortisol levels in saliva is an important biomarker of stress and its rapid detection is a significant need for overall management of health and wellness. Herein, we demonstrate two novel SERS-based approaches for the detection of cortisol directly in saliva using regular and novel hexagonal gold nanoparticles (AuNPs) on a paper substrate. Using the direct SERS method, we first show the detection of cortisol by mixing the cortisol solution with highly concentrated AuNPs on a Parchment paper surface as an active SERS substrate. We also propose an alternate lateral flow SERS (LFS) approach, which employs paper as a chromatographic channel to reduce interference from background saliva matrix for the detection using SERS. A rapid detection of spiked cortisol in saliva down to 100 ig/ml concentration by employing the 'lateral flow SERS' (LFS) platform is shown. Results indicate a promising route for point-of-care detection of stress biomarkers.

引用

页码：719 / 722

页数：4

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