Study on specific mucosal immunity by intranasal immunization of outer membrane protein P6 of Haemophilus influenzae with cholera toxin B subunit

被引：0
|
作者：
Hotomi, M
Yokoyama, M
Kuki, K
Togawa, A
Yamanaka, N
机构：
来源：
ACTA OTO-LARYNGOLOGICA | 1996年
关键词：
H-influenzae; P6; cytokine; intranasal immunization;
D O I：
暂无
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Effective induction of the specific mucosal immunity against the outer membrane protein P6 of Haemophilus influenzae was investigated. Twenty-four BALB/c mice were intranasally immunized with P6, twice, with 2 weeks in between, with or without intranasal cytokine treatment. The intranasal immunization evoked both anti-P6 specific mucosal IgA immunity and systemic IgG immunity. In addition, intranasal administration of rIL-2 and rIL-5 enhanced anti-Pb specific immune response was maintained for 3 weeks after the final immunization with the intranasal cytokine treatment. These suggest the possibility of intranasal immunization and the advantage of intranasal administration of cytokines for eliciting both mucosal and systemic immunity.
引用
收藏
页码：150 / 152
页数：3
相关论文
共 50 条
  • [21] Intranasal Immunization with Nontypeable Haemophilus influenzae Outer Membrane Vesicles Induces Cross-Protective Immunity in Mice
    Roier, Sandro
    Leitner, Deborah R.
    Iwashkiw, Jeremy
    Schild-Pruefert, Kristina
    Feldman, Mario F.
    Krohne, Georg
    Reidl, Joachim
    Schild, Stefan
    PLOS ONE, 2012, 7 (08):
  • [22] Investigation of nontypeable Haemophilus influenzae outer membrane protein P6 as a new carrier for lipooligosaccharide conjugate vaccines
    Wu, TH
    Chen, J
    Murphy, TF
    Green, BA
    Gu, XX
    VACCINE, 2005, 23 (44) : 5177 - 5185
  • [23] Purification and characterization of outer membrane protein P6, a vaccine antigen of non-typeable Haemophilus influenzae
    Karalus, RJ
    Murphy, TF
    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1999, 26 (02): : 159 - 166
  • [24] Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and α-galactosylceramide
    Noda, Kenji
    Kodama, Satoru
    Umemoto, Shingo
    Nomi, Nozomi
    Hirano, Takashi
    Suzuki, Masashi
    MICROBIOLOGY AND IMMUNOLOGY, 2011, 55 (08) : 574 - 581
  • [25] Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media
    DeMaria, TF
    Murwin, DM
    Leake, ER
    INFECTION AND IMMUNITY, 1996, 64 (12) : 5187 - 5192
  • [26] Adenoid lymphocyte responses to outer membrane protein P6 of nontypable Haemophilus influenzae in children with and without otitis media
    Kodama, H
    Faden, H
    Harabuchi, Y
    Kataura, A
    Bernstein, JM
    Brodsky, L
    ACTA OTO-LARYNGOLOGICA, 1996, : 153 - 154
  • [27] Effect of lipid modification on the physicochemical, structural, antigenic and immunoprotective properties of Haemophilus influenzae outer membrane protein P6
    Yang, YP
    Munson, RS
    Grass, S
    Chong, P
    Harkness, RE
    Gisonni, L
    James, O
    Kwok, Y
    Klein, MH
    VACCINE, 1997, 15 (09) : 976 - 987
  • [28] Detection of Haemophilus influenzae by loop-mediated isothermal amplification (LAMP) of the outer membrane protein P6 gene
    Torigoe, Hirotaka
    Seki, Mitsuko
    Yamashita, Yoshihisa
    Sugaya, Atsuto
    Maeno, Masao
    JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2007, 60 (01) : 55 - 58
  • [29] Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines
    Berenson, CS
    Murphy, TF
    Wrona, CT
    Sethi, S
    INFECTION AND IMMUNITY, 2005, 73 (05) : 2728 - 2735
  • [30] ENHANCED RESPIRATORY CLEARANCE OF NONTYPABLE HAEMOPHILUS-INFLUENZAE FOLLOWING MUCOSAL IMMUNIZATION WITH P6 IN A RAT MODEL
    KYD, JM
    DUNKLEY, ML
    CRIPPS, AW
    INFECTION AND IMMUNITY, 1995, 63 (08) : 2931 - 2940
12345