Microbial reduction of alpha-substituted-alpha-acetyl-gamma-butyrolactones

被引：9
|
作者：
Ribeiro, Joyce B. [1 ]
Sousa, L. M. A. [1 ]
Fraga, C. A. M. [1 ,2 ]
Leite, Selma G. F. [3 ]
Ramos, M. C. K. V. [1 ]
de Aquino Neto, F. R. [1 ]
Aguiar, L. C. S. [4 ]
de Souza, Rodrigo O. M. A. [1 ,4 ]
Antunes, O. A. C. [1 ,4 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Quim, BR-21941909 Rio de Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Fac Farm, BR-21941614 Rio de Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Escola Quim, BR-21941909 Rio de Janeiro, Brazil
[4] Univ Fed Rio de Janeiro, NPPN, BR-21941614 Rio de Janeiro, Brazil
来源：
CATALYSIS COMMUNICATIONS | 2008年 / 9卷 / 08期
关键词：
yeasts; mold; reduction; chiral;
D O I：
10.1016/j.catcom.2008.02.012
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The microbial reduction of alpha-methyl, allyl and benzyl derivatives of alpha-acetyl-gamma-butyrolactones was carried out. It has been shown that different microorganisms, Kluyveromyces marxianus, Hansenula sp., Geotrichum candidum and Aspergillus niger, arc capable to carry out the enantiospecific/selective reduction of these compounds. In the examples studied K marxianus afforded the best results in terms of diastereo and enantioselectivity. It was found that depending on the particular microorganism used, a particular enantiomer can be obtained. Since these microorganisms are wild type, that is, are not engineered, they are robust and can be used to scale up these processes, which is going to be the next step of our study. It has been definitively proved that this microbial reduction occurs via the keto form, so clarifying the mechanism of these reactions firstly carried out with unsubstituted compounds. (c) 2008 Elsevier B.V. All rights reserved.
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页码：1782 / 1786
页数：5
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