Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

被引：19
|
作者：
Hojo, Keiko [1 ]
Ichikawa, Hideki
Onishi, Mare
Fukumori, Yoshinobu
Kawasaki, Koichi
机构：
[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Chou Ku, Kobe, Hyogo 6508586, Japan
来源：
JOURNAL OF PEPTIDE SCIENCE | 2011年 / 17卷 / 07期
关键词：
nanoparticles; suspension; solution-phase synthesis; peptide synthesis in water; Boc strategy; green chemistry; N-PROTECTING GROUP; PARTICLE-SIZE REDUCTION; ESTERS; TETRAFLUOROBORATE;
D O I：
10.1002/psc.1367
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in-water solution-phase peptide synthesis method using Boc-amino acids. It is based on a coupling reaction utilizing suspended water-dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity. Copyright (C) 2011 European Peptide Society and JohnWiley & Sons, Ltd.
引用
收藏
页码：487 / 492
页数：6
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