Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer

被引:2
|
作者
Berlato, Chiara [1 ]
Kahn, Moddasar N. [1 ]
Schioppa, Tiziana [1 ]
Thompson, Richard [1 ]
Maniati, Eleni [1 ]
Canosa, Monica [1 ]
Kulbe, Hagen [1 ]
Sheldon, Chris [2 ]
Wreggett, Keith [3 ]
Hagemann, Urs [4 ]
Duncan, Alexander [4 ]
Fletcher, Laura [5 ]
Wilkinson, Robert W. [6 ]
Powles, Thomas [1 ]
Quezada, Sergio [7 ]
Balkwill, Frances [1 ]
机构
[1] Barts Canc Inst, London, England
[2] Astra Zeneca, Alderley Pk, Cheshire, England
[3] Astra Zeneca, Loughborough, Leics, England
[4] Affitech, Oslo, Norway
[5] Canc Res Technol Ltd, London, England
[6] MedImmune Ltd, Cambridge, England
[7] UCL Canc Inst, London, England
关键词
D O I
10.1158/1538-7445.AM2014-1076
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1076
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
    Wang, Y
    Zhang, YM
    Yang, X
    Han, WL
    Liu, YN
    Xu, QM
    Zhao, R
    Di, CH
    Song, QS
    Ma, DL
    LIFE SCIENCES, 2006, 78 (06) : 614 - 621
  • [22] Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells
    Olkhanud, Purevdorj B.
    Baatar, Dolgor
    Bodogai, Monica
    Hakim, Fran
    Gress, Ronald
    Anderson, Robin L.
    Deng, Jie
    Xu, Mai
    Briest, Susanne
    Biragyn, Arya
    CANCER RESEARCH, 2009, 69 (14) : 5996 - 6004
  • [23] Distinct Conformations of the Chemokine Receptor CCR4 with Implications for Its Targeting in Allergy
    Viney, Jonathan M.
    Andrew, David P.
    Phillips, Rhian M.
    Meiser, Andrea
    Patel, Pallavi
    Lennartz-Walker, Melissa
    Cousins, David J.
    Barton, Nicholas P.
    Hall, David A.
    Pease, James E.
    JOURNAL OF IMMUNOLOGY, 2014, 192 (07): : 3419 - 3427
  • [24] Lung metastasis of breast cancer cells is mediated by chemokine receptor CCR4 but regulated by immune cells
    Olkhanud, Purevdorj
    Damdinsuren, Bazarragcha
    Bodogai, Monica
    Baatar, Dolgor
    Anderson, Robin
    Sen, Ranjan
    Biragyn, Arya
    CLINICAL & EXPERIMENTAL METASTASIS, 2009, 26 (07) : 867 - 868
  • [25] Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists
    Miah, Afjal H.
    Copley, Royston C. B.
    O'Flynn, Daniel
    Percy, Jonathan M.
    Procopiou, Panayiotis A.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 12 (11) : 1779 - 1792
  • [26] Expression of CC chemokine receptor 4 (CCR4) mRNA in canine atopic skin lesion
    Maeda, S
    Okayama, T
    Omori, K
    Masuda, K
    Sakaguchi, M
    Ohno, K
    Tsujimoto, H
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2002, 90 (3-4) : 145 - 154
  • [27] The expression of chemokine receptor CXCR3 and CCR4 in RA and SLE.
    Tamiya, H
    Tani, K
    Sone, S
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S256 - S257
  • [28] THE CCR4 CHEMOKINE RECEPTOR ANTAGONIST CCX6239 FOR THE TREATMENT OF ALLERGIC DISEASES
    Miao, Z.
    Wang, Y.
    Leleti, M.
    Dairaghi, D.
    Walters, M.
    Sullivan, T.
    Miao, S.
    Schall, T.
    Jaen, J.
    Powers, J.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2013, 111 (05) : A108 - A109
  • [29] The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
    Campbell, JJ
    Haraldsen, G
    Pan, J
    Rottman, J
    Qin, S
    Ponath, P
    Andrew, DP
    Warnke, R
    Ruffing, N
    Kassam, N
    Wu, L
    Butcher, EC
    NATURE, 1999, 400 (6746) : 776 - 780
  • [30] The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
    J. J. Campbell
    G. Haraldsen
    J. Pan
    J. Rottman
    S. Qin
    P. Ponath
    D. P. Andrew
    R. Warnke
    N. Ruffing
    N. Kassam
    L. Wu
    E. C. Butcher
    Nature, 1999, 400 : 776 - 780