The Impact of Epitranscriptomics on Antiviral Innate Immunity

被引：1
|
作者：
Mersinoglu, Beril [1 ]
Cristinelli, Sara [1 ]
Ciuffi, Angela [1 ]
机构：
[1] Univ Lausanne, Lausanne Univ Hosp, Inst Microbiol, CH-1011 Lausanne, Switzerland
来源：
VIRUSES-BASEL | 2022年 / 14卷 / 08期
基金：
瑞士国家科学基金会;
关键词：
epitranscriptomics; antiviral immunity; RIG-I sensing; IFN-I response; viral infection; DYNAMIC RNA MODIFICATIONS; PRE-MESSENGER-RNA; HEPATITIS-B; NUCLEAR-RNA; 2'-O-RIBOSE METHYLATION; STRUCTURAL INSIGHTS; M(6)A MODIFICATION; HOST RESTRICTION; GENE-EXPRESSION; VACCINIA VIRUS;
D O I：
10.3390/v14081666
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Epitranscriptomics, i.e., chemical modifications of RNA molecules, has proven to be a new layer of modulation and regulation of protein expression, asking for the revisiting of some aspects of cellular biology. At the virological level, epitranscriptomics can thus directly impact the viral life cycle itself, acting on viral or cellular proteins promoting replication, or impacting the innate antiviral response of the host cell, the latter being the focus of the present review.
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页数：32
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