Synthesis and characterization of Schiff bases of aminothiazolylbromo coumarin for their analgesic and anti-inflammatory activity

被引：0
|
作者：
Venugopala, KN [1 ]
Jayashree, BS [1 ]
机构：
[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, Karnataka, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2004年 / 16卷 / 01期
关键词：
synthesis; coumarin; thiazole; Schiff bases; analgesic and anti-inflammatory activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some of the Schiff bases of aminothiazolylbromocoumarin are synthesized by the reaction between 2'-amino-4'-(6-bromo-3-coumarinyl) thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-bromocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for analgesic and anti-inflammatory activity by acetic acid-induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Some of the compounds have shown interesting biological activity based on the presence of certain functional groups.
引用
收藏
页码：407 / 411
页数：5
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